Evidence map›Paper›PMID 39669300›Full record

SynthesisRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2024

Metformin versus insulin in gestational diabetes mellitus: a systematic review.

Giovanna Noronha Berti, Igor Gutschov Oviedo Garcia, João Pedro Ruas Floriano de Toledo, Júlia Rodrigues Tatemoto, Lais Watanabe Marino, Mariana de Medeiros Legori, Sérgio Floriano de Toledo

Abstract readSystematic ReviewComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Giovanna Noronha BertiCentro Universitário Lusíada SantosSP Brazil Centro Universitário Lusíada, Santos, SP, Brazil.ORCID https://orcid.org/0009-0005-8004-1973
Igor Gutschov Oviedo GarciaCentro Universitário Lusíada SantosSP Brazil Centro Universitário Lusíada, Santos, SP, Brazil.ORCID https://orcid.org/0000-0003-4218-0049
João Pedro Ruas Floriano de ToledoCentro Universitário Lusíada SantosSP Brazil Centro Universitário Lusíada, Santos, SP, Brazil.ORCID https://orcid.org/0009-0007-7079-0086
Júlia Rodrigues TatemotoCentro Universitário Lusíada SantosSP Brazil Centro Universitário Lusíada, Santos, SP, Brazil.ORCID https://orcid.org/0009-0009-1952-6903
Lais Watanabe MarinoCentro Universitário Lusíada SantosSP Brazil Centro Universitário Lusíada, Santos, SP, Brazil.ORCID https://orcid.org/0000-0001-9662-1597
Mariana de Medeiros LegoriCentro Universitário Lusíada SantosSP Brazil Centro Universitário Lusíada, Santos, SP, Brazil.ORCID https://orcid.org/0000-0003-2593-3627
Sérgio Floriano de ToledoCentro Universitário Lusíada SantosSP Brazil Centro Universitário Lusíada, Santos, SP, Brazil.ORCID https://orcid.org/0000-0002-3576-6765

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The aim of this study is to assess the use of metformin with or without insulin for the treatment of Gestational Diabetes Mellitus compared to insulin alone. Data sources: This article consists of a systematic review of randomized clinical trials. The searches were carried out on MEDLINE including 7 studies, between 2010 to 2021. Study selection: Randomized clinical trials comparing metformin and insulin written in English, Spanish or Portuguese, with no time limit, were included. Data collection: Data was extracted from all the 7 articles and compared statistically when possible. Whenever data was not available or couldn't be statistically compared, the main results were described in detail. Data synthesis: Insulin alone is not superior than metformin with or without insulin on gestational diabetes mellitus. Conclusion: There is a potential viability of using metformin as an alternative compared to insulin alone in the treatment of Gestational Diabetes Mellitus. However, all assessed outcomes have a very low level of certainty of evidence and more studies are necessary to support these findings.

Indexed as

Diabetes, GestationalHypoglycemic AgentsInsulinMetforminDrug Therapy, CombinationFemaleHumansPregnancyRandomized Controlled Trials as TopicHypoglycemic AgentsInsulinMetforminGestational diabetesInsulin therapyMetforminPregnancy complications

Identifiers

PMID39669300
PMCPMC11637449

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.