Evidence map›Paper›PMID 39669690›Full record

ArticleCytotechnology2025

Phillygenin regulates the colorectal cancer tumor microenvironment by inhibiting hypoxia-inducible factor 1 alpha.

Tianhao Chu, Yidi Ning, Mingqian Ma, Zhenying Zhao, Jun Liu, Wei Wang, Xueer Yu, Yijia Wang, Shiwu Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tianhao Chu *Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Yidi Ning *Nankai University School of Medicine, Nankai University, Tianjin, China.
Mingqian MaGraduate School of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Zhenying ZhaoTianjin Institute of Coloproctology, Tianjin Union Medical Center, 190 Jieyuan Road, Hongqiao, Tianjin, 300121 China.
Jun LiuDepartment of Radiology, The Fourth Central Hospital Affiliated to Nankai University, Tianjin, China.
Wei WangTEDA Institute of Biological Sciences and Biotechnology, Nankai University, Tianjin, China.
Xueer YuSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Yijia WangTianjin Institute of Coloproctology, Tianjin Union Medical Center, 190 Jieyuan Road, Hongqiao, Tianjin, 300121 China.ORCID 0000-0002-4026-9245
Shiwu ZhangDepartment of Pathology, Tianjin Union Medical Center, 190 Jieyuan Road, Hongqiao, Tianjin, 300121 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tumor microenvironment (TME) is important in the recurrence and metastasis of colorectal cancer (CRC). Phillygenin is an effective component of Supplementary Information: The online version contains supplementary material available at 10.1007/s10616-024-00679-2.

Indexed as

Colorectal cancerHIF-1αImmune responsePhillygeninTumor microenvironment

Identifiers

PMID39669690
PMCPMC11631830

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.