Evidence map›Paper›PMID 39670345›Full record

ArticleChembiochem : a European journal of chemical biology2025

Unraveling the Molecular Basis for G-Quadruplex-Binders to ALS/FTD-Associated G4C2 Repeats of the C9orf72 Gene.

Luisa D'Anna, Darren Wragg, Daniela Mauro, Simona Rubino, Alessio Terenzi, Giampaolo Barone, Sophie R Thomas, Angela Casini, Riccardo Bonsignore, Angelo Spinello

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Luisa D'AnnaDepartment of Biological, Chemical, and Pharmaceutical Sciences, Technologies, Università di Palermo, Viale delle Scienze Edificio 17, 90128, Palermo, Italy.
Darren WraggChair of Medicinal and Bioinorganic Chemistry, School of Natural Sciences, Department of Chemistry, Technical University of Munich (TUM), Lichtenbergstr. 4, 85748, Garching b. München, Germany.
Daniela MauroDepartment of Biological, Chemical, and Pharmaceutical Sciences, Technologies, Università di Palermo, Viale delle Scienze Edificio 17, 90128, Palermo, Italy.
Simona RubinoDepartment of Biological, Chemical, and Pharmaceutical Sciences, Technologies, Università di Palermo, Viale delle Scienze Edificio 17, 90128, Palermo, Italy.
Alessio TerenziDepartment of Biological, Chemical, and Pharmaceutical Sciences, Technologies, Università di Palermo, Viale delle Scienze Edificio 17, 90128, Palermo, Italy.
Giampaolo BaroneDepartment of Biological, Chemical, and Pharmaceutical Sciences, Technologies, Università di Palermo, Viale delle Scienze Edificio 17, 90128, Palermo, Italy.
Sophie R ThomasDepartment of Inorganic Chemistry, University of Vienna, Währinger Straße. 42, Vienna, Austria.
Angela CasiniChair of Medicinal and Bioinorganic Chemistry, School of Natural Sciences, Department of Chemistry, Technical University of Munich (TUM), Lichtenbergstr. 4, 85748, Garching b. München, Germany.
Riccardo BonsignoreDepartment of Biological, Chemical, and Pharmaceutical Sciences, Technologies, Università di Palermo, Viale delle Scienze Edificio 17, 90128, Palermo, Italy.ORCID https://orcid.org/0000-0003-2699-4384
Angelo SpinelloDepartment of Biological, Chemical, and Pharmaceutical Sciences, Technologies, Università di Palermo, Viale delle Scienze Edificio 17, 90128, Palermo, Italy.ORCID https://orcid.org/0000-0002-8387-8956

Funding

European Union-NextGenerationEU B73C22001250006European Union-NextGenerationEU PE_00000019European Union-NextGenerationEU PNRR-M4C2-I1.3
6 · The paper itself

Abstract

The most recurrent familial cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of an abnormal number of intronic GGGGCC (G

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinFrontotemporal DementiaG-QuadruplexesFluorescence Resonance Energy TransferHumansC9orf72 ProteinC9orf72 protein, humanC9orf72dockingG-quadruplexmolecular dynamicsneurodegenerative disorders

Identifiers

PMID39670345
PMCPMC12007073

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.