Evidence map›Paper›PMID 39670513›Full record

ArticleBiochemistry2025

Identification of Amino Acid Residues Critical for the Interaction of Fibrin with N-Cadherin.

Sergiy Yakovlev, David A Nyenhuis, Nico Tjandra, Dudley K Strickland, Leonid Medved

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sergiy YakovlevCenter for Vascular and Inflammatory Diseases and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.ORCID 0000-0002-2078-5218
David A NyenhuisBiochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
Nico TjandraBiochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0001-6365-5811
Dudley K StricklandCenter for Vascular and Inflammatory Diseases and Departments of Surgery and Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.ORCID 0000-0001-7526-5917
Leonid MedvedCenter for Vascular and Inflammatory Diseases and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.ORCID 0000-0002-3665-9849

Funding

FIBRIN(OGEN) STRUCTURE AND INTERACTIONSR01HL056051 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI LEONID V. MEDVED · 1998 to 2026
$9.1M
Role of LDL receptor family members in protecting the vasculatureR35HL135743 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI STRICKLAND, DUDLEY K. · 2017 to 2023
$5.4M
LRP1-tau interactions and Alzheimer DiseaseR01AG073236 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI HYMAN, BRADLEY T., STRICKLAND, DUDLEY K. · 2024 to 2025
$1.6M
NHLBI NIH HHS R01 HL056051NHLBI NIH HHS R35 HL135743NIA NIH HHS R01 AG073236
6 · The paper itself

Abstract

We recently identified N-cadherin as a novel receptor for fibrin and localized complementary binding sites within the fibrin βN-domains and the third and fifth extracellular domains (EC3 and EC5) of N-cadherin. We also hypothesized that the His16 and Arg17 residues of the βN-domains and the (Asp/Glu)-X-(Asp/Glu) motifs present in the EC3 and EC5 domains may play roles in the interaction between fibrin and N-cadherin. The primary objectives of this study were to test these hypotheses and to further clarify the structural basis for this interaction. To test our hypotheses, we first mutated His16 and Arg17 in the recombinant (β15-66)

Indexed as

CadherinsFibrinAmino Acid MotifsAmino AcidsAmino Acid SequenceBinding SitesHumansModels, MolecularMutagenesis, Site-DirectedProtein BindingProtein DomainsAmino AcidsCadherinsFibrin

Identifiers

PMID39670513
PMCPMC11892114

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.