Evidence map›Paper›PMID 39670672›Full record

ArticlePharmaceutical biology2025

Lan-Chi Hsieh, Shu-Ling Hsieh, Tsu-Ni Ping, Yi-Chun Huang, Ssu-Jung Lin, Hsing-Yu Chi, Chih-Chung Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Molecules (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lan-Chi HsiehDepartment of Dietetics, Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan, R.O.C.
Shu-Ling HsiehDepartment of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan, R.O.C.
Tsu-Ni PingDepartment of Food and Nutrition, Providence University, Taichung, Taiwan, R.O.C.
Yi-Chun HuangDepartment of Food and Nutrition, Providence University, Taichung, Taiwan, R.O.C.
Ssu-Jung LinDepartment of Food and Nutrition, Providence University, Taichung, Taiwan, R.O.C.
Hsing-Yu ChiDepartment of Food and Nutrition, Providence University, Taichung, Taiwan, R.O.C.
Chih-Chung WuDepartment of Food and Nutrition, Providence University, Taichung, Taiwan, R.O.C.ORCID 0000-0002-6518-5312

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

objectiveTo investigate the effects of MATERIALS AND

methodsA-549 cells were treated with AGWE for 24 h and then stimulated with 10 μg/mL LPS for another 24 h. The effects of AGWE on cell viability, the inflammatory response, oxidative stress, and apoptosis and their regulatory factors, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and NLR family pyrin domain containing 3 (NLRP3) inflammasome signaling activation were analyzed.

resultsTreatment with 5-50 μg/mL AGWE reversed the decrease in cell viability caused by LPS (

conclusionsThese results show that 10 and 50 μg/mL AGWE can reduce the acute inflammation induced by LPS by reducing NF-κB and NLRP3 inflammasome signaling and mitochondria-dependent apoptosis pathways.

Indexed as

Acute Lung InjuryCell SurvivalInflammasomesLipopolysaccharidesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinPlant ExtractsSignal TransductionA549 CellsAnti-Inflammatory AgentsApoptosisDose-Response Relationship, DrugHumansOxidative StressAnti-Inflammatory AgentsInflammasomesLipopolysaccharidesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanPlant Extractsacute lung injuryApium graveolens L. (celery;)apoptosisNF-κBNLRP3 inflammasome

Identifiers

PMID39670672
PMCPMC11648134

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.