Evidence map›Paper›PMID 39671039›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Murine Models to Study Crimean-Congo Hemorrhagic Fever Hepatic Injury.

Joseph W Golden, Aura R Garrison, Xiankun Zeng

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph W GoldenUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA. joseph.w.golden.civ@health.mil.
Aura R GarrisonUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
Xiankun ZengUnited States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crimean-Congo hemorrhagic fever virus (CCHFV) is a member of the family Nairoviridae in the Hareavirales order and is an important human pathogen. Hepatic injury is a salient feature of CCHF human disease and can be recapitulated in murine models. Here, we described techniques to study liver damage caused by CCHFV in the mouse system. These techniques include a description of the mouse model used to study disease, and classical histopathological methods. Additionally, the use of in situ hybridization to evaluate liver injury is described in the context of viral infection. Immunofluorescence staining techniques to identify infected and/or damaged Kupffer cells is also explained. This work provides a primer for the comprehensive pathophysiological study of liver infection by a virus, but also has utility for noninfectious liver injury as well.

Indexed as

Disease Models, AnimalHemorrhagic Fever, CrimeanHemorrhagic Fever Virus, Crimean-CongoLiverAnimalsHumansIn Situ HybridizationKupffer CellsMiceCrimean-Congo hemorrhagic fever virusHepatic injuryHepatocyteIn situ hybridizationKupffer cellsLiver damageNairovirusesViral infection

Identifiers

PMID39671039

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.