Evidence map›Paper›PMID 39671149›Full record

ArticleEndocrine2025

Validation of ACR TI-RADS performance in transition age: results from a multicenter retrospective study by the TALENT study group.

Giorgio Grani, Ilaria Stramazzo, Pietro Locantore, Camilla Virili, Tiziana Filardi, Claudio Lecis, Roberta Centello, Gianluca Cera, Maria Giulia Santaguida, Daniele Gianfrilli and 4 more

Abstract readMulticenter StudyValidation Study
PubMed Publisher
In one paragraph

Article in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giorgio Grani *Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Ilaria Stramazzo *Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Pietro LocantoreEndocrinology Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Camilla ViriliEndocrinology Unit, Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Latina, Italy.
Tiziana FilardiDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy.
Claudio LecisDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Roberta CentelloDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Gianluca CeraEndocrinology Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Maria Giulia SantaguidaEndocrinology Unit, AUSL, Latina, Italy.
Daniele GianfrilliDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Andrea M IsidoriDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Cosimo DuranteDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy. Cosimo.durante@uniroma1.it.
Carlotta PozzaDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy. carlotta.pozza@uniroma1.it.
TALENT group

Funding

Italian Ministry of University and Research under PNRR - M4C2-I1.3 Project PE_00000019 "HEAL ITALIA" CUP B53C22004000006
6 · The paper itself

Abstract

purposeAlthough thyroid nodules are less common in the pediatric population, the risk of malignancy is higher than in adult patients. The aim of this study was to evaluate the ultrasonographic predictive factors of malignancy in thyroid nodules and to validate American College of Radiologists (ACR) TI-RADS performance in transition age patients.

methodsOne hundred forty-two patients aged between 14 and 21 years referred to the participating centers for FNA biopsy of a thyroid nodule between 2007 and 2022 were included and ultrasound reports and sonographic images were retrospectively analyzed. Nodule features were defined according to the ACR-TIRADS lexicon. Two reference standards were applied: FNA cytology and surgical histology. The diagnostic performance of single sonographic features was estimated. Significant predictors were then included in a multivariate regression model.

resultsNodules included in ACR-TIRADS categories TR4 or TR5 had 10-fold increased risk of indeterminate or suspicious/malignant cytology [p < 0.001]. In univariate analysis, solid composition [p = 0.016] and presence of hyperechoic foci [p = 0.040] significantly increased the likelihood of malignant histology. In multivariate regression analysis, irregular margins [p = 0.011] and hyperechoic foci [p = 0.019] were independent predictors of indeterminate or suspicious/malignant cytology.

conclusionNodules included in ACR-TIRADS categories TR4 or TR5 had 10-fold increased risk of indeterminate or suspicious/malignant cytology in transition age. ACR-TIRADS was not able to rule-out malignancy compared to FNAB alone, suggesting the need to reconsider recommendations in the transition age group.

Indexed as

Thyroid GlandThyroid NeoplasmsThyroid NoduleAdolescentBiopsy, Fine-NeedleFemaleHumansMaleRetrospective StudiesUltrasonographyYoung AdultACR TI-RADSFine needle aspirationThyroid nodulesTransition ageUltrasonography

Identifiers

PMID39671149

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.