Evidence map›Paper›PMID 39671480›Full record

ArticleScience advances2024

Smart control lipid-based nanocarriers for fine-tuning gut hormone secretion.

Yining Xu, Cécilia Bohns Michalowski, Jackie Koehler, Tamana Darwish, Nunzio Guccio, Constanza Alcaino, Inês Domingues, Wunan Zhang, Valentina Marotti, Matthias Van Hul and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yining XuLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Université catholique de Louvain, 1200 Brussels, Belgium.ORCID 0000-0001-6201-9338
Cécilia Bohns MichalowskiLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Université catholique de Louvain, 1200 Brussels, Belgium.
Jackie KoehlerLunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0009-0009-3308-3707
Tamana DarwishInstitute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK.
Nunzio GuccioInstitute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK.
Constanza AlcainoInstitute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK.ORCID 0000-0001-9595-4330
Inês DominguesLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Université catholique de Louvain, 1200 Brussels, Belgium.ORCID 0000-0002-1240-9060
Wunan ZhangLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Université catholique de Louvain, 1200 Brussels, Belgium.
Valentina MarottiLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Université catholique de Louvain, 1200 Brussels, Belgium.ORCID 0000-0002-7273-0868
Matthias Van HulLouvain Drug Research Institute, Metabolism and Nutrition Group, Université catholique de Louvain, 1200 Brussels, Belgium.ORCID 0000-0002-5503-107X
Paola PaoneLouvain Drug Research Institute, Metabolism and Nutrition Group, Université catholique de Louvain, 1200 Brussels, Belgium.
Melitini KoutsovitiDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Denmark.ORCID 0000-0003-0164-226X
Ben J BoydDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen Ø, Denmark.ORCID 0000-0001-5434-590X
Daniel J DruckerLunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0001-6688-8127
Patrice D CaniLouvain Drug Research Institute, Metabolism and Nutrition Group, Université catholique de Louvain, 1200 Brussels, Belgium.ORCID 0000-0003-2040-2448
Frank ReimannInstitute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK.ORCID 0000-0001-9399-6377
Fiona M GribbleInstitute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK.ORCID 0000-0002-4232-2898
Ana BeloquiLouvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Université catholique de Louvain, 1200 Brussels, Belgium.ORCID 0000-0003-4221-3357

Funding

European Research CouncilMedical Research CouncilWellcome Trust
6 · The paper itself

Abstract

Modulating the endogenous stores of gastrointestinal hormones is considered a promising strategy to mimic gut endocrine function, improving metabolic dysfunction. Here, we exploit mouse and human knock-in and knockout intestinal organoids and show that agents used as commercial lipid excipients can activate nutrient-sensitive receptors on enteroendocrine cells (EECs) and, when formulated as lipid nanocarriers, can bestow biological effects through the release of GLP-1, GIP, and PYY from K and L cells. Studies in wild-type, dysglycemic, and gut

Indexed as

Enteroendocrine CellsGastrointestinal HormonesLipidsNanoparticlesAnimalsDrug CarriersGlucagon-Like Peptide 1HumansMiceMice, KnockoutOrganoidsPeptide YYDrug CarriersGastrointestinal HormonesGlucagon-Like Peptide 1LipidsPeptide YY

Identifiers

PMID39671480
PMCPMC11641013

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.