Evidence map›Paper›PMID 39672953›Full record

ArticleNature biotechnology2025

A general system for targeting MHC class II-antigen complex via a single adaptable loop.

Haotian Du, Jingjia Liu, Kevin M Jude, Xinbo Yang, Ying Li, Braxton Bell, Hongli Yang, Audrey Kassardjian, Wyatt Blackson, Ali Mobedi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Haotian Du *Department of Chemistry, Stanford University, Stanford, CA, USA.
Jingjia Liu *Department of Bioengineering, Stanford University, Stanford, CA, USA.
Kevin M JudeDepartments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3675-5136
Xinbo YangDepartments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Ying LiDepartment of Pediatrics, Divisions of Human Gene Therapy and Allergy, Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.
Braxton BellDepartment of Chemistry, Stanford University, Stanford, CA, USA.
Hongli YangDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Audrey KassardjianProgram in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-5141-5132
Wyatt BlacksonDepartment of Chemical Engineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2452-5915
Ali MobediDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Udit ParekhDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
R Andres Parra SperbergDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Jean-Philippe JulienProgram in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-7602-3995
Elizabeth D MellinsDepartment of Pediatrics, Divisions of Human Gene Therapy and Allergy, Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2577-139X
K Christopher GarciaDepartments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9273-0278
Po-Ssu HuangDepartment of Bioengineering, Stanford University, Stanford, CA, USA. possu@stanford.edu.ORCID http://orcid.org/0000-0002-7948-2895

Funding

cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Structural correlates of T cell receptor signalingR01AI103867 · NIAID · STANFORD UNIVERSITY · PI Kenan Christopher GARCIA · 2014 to 2026
$5.3M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
MHC Variation in Host Response to SARS-CoV2 and COVID-19 OutcomesR01AI159260 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLLENBACH, JILL ALLISON · 2021 to 2025
$4.0M
Graduate Training Program in BiotechnologyT32GM141819 · NIGMS · STANFORD UNIVERSITY · PI Eric Andrew Appel, Fan Yang · 2021 to 2026
$1.9M
Generative neural networks for structure-based antibody designR01GM147893 · NIGMS · STANFORD UNIVERSITY · PI Possu Huang · 2022 to 2026
$1.9M
American Cancer Society (American Cancer Society, Inc.) 134055-IRG-218National Science Foundation (NSF) 2216011NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS R01 AI103867NIAID NIH HHS R01 AI159260NIDA NIH HHS 75N95020D00005NIGMS NIH HHS R01 GM147893NIGMS NIH HHS T32 GM141819ORFDO NIH HHS 75N99020D00005U.S. Department of Health & Human Services | National Institutes of Health (NIH) T32GM141819U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 5R01AI103867U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI159260U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM147893
6 · The paper itself

Abstract

Major histocompatibility complex class II (MHCII) bound to a peptide antigen mediates interactions between CD4

Indexed as

Histocompatibility Antigens Class IIHumansPeptidesProtein BindingReceptors, Antigen, T-CellSARS-CoV-2Histocompatibility Antigens Class IIPeptidesReceptors, Antigen, T-Cell

Identifiers

PMID39672953
PMCPMC12399433

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.