Evidence mapPaperPMID 39673041Full record

ArticleCell biochemistry and biophysics2025

Exploring Thiazolidinedione-Naphthalene Analogues as Potential Antidiabetic Agents: Design, Synthesis, Molecular Docking and In-vitro Evaluation.

Sharfuddin Mohd, Vikas Sharma, Vancha Harish, Rakesh Kumar, Govindaiah Pilli

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Article in Cell biochemistry and biophysics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Synthesis andACS medicinal chemistry letters · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sharfuddin MohdSchool of pharmaceutical sciences, Lovely Professional University, Phagwara, Punjab, India.
Vikas SharmaSchool of pharmaceutical sciences, Lovely Professional University, Phagwara, Punjab, India.
Vancha HarishSchool of pharmaceutical sciences, Lovely Professional University, Phagwara, Punjab, India.
Rakesh KumarSchool of pharmaceutical sciences, Lovely Professional University, Phagwara, Punjab, India.
Govindaiah PilliFaculty of medicine, Department of Pathology, Wayne state University, Detroit, MI, USA. govipharma@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thiazolidinedione-naphthalene analogues were synthesized and evaluated for antidiabetic activity as Pancreatic α-Amylase (PAA) and intestinal α-glucosidase (IAG) inhibitors. The activity of the compounds (14a-g,17a-k) is compared with acarbose as the standard drug and all the compounds shows good to moderate antidiabetic activity. In-vitro PAA and IAG inhibition assay is performed for the all compounds, the compounds 17e shows superior PAA and IAG inhibitory activity with respective to standard (IC

Indexed as

Drug DesignHypoglycemic AgentsMolecular Docking SimulationNaphthalenesThiazolidinedionesalpha-Amylasesalpha-GlucosidasesAntioxidantsGlycoside Hydrolase InhibitorsHumansPancreasalpha-Amylasesalpha-GlucosidasesAntioxidantsGlycoside Hydrolase InhibitorsHypoglycemic AgentsNaphthalenesThiazolidinedionesAntioxidantDiabetesIntestinal α-glucosidaseNaphthalenePancreatic α-amylaseThiazolidinediones

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.