Evidence map›Paper›PMID 39673053›Full record

Trial reportSleep & breathing = Schlaf & Atmung2024

Examining the impact of obstructive sleep apnea on cognitive function in severe COPD.

Kristina Kock Hansen, Anders Løkke, Hanne Irene Jensen, Eline Kirstine Gantzhorn, Ingeborg Farver-Vestergaard, Ole Hilberg

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep & breathing = Schlaf & Atmung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04458038 (Does Chronic Obstructive Lung Disease Influence the Cognitive Function), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04458038 naunknown statusnot on this map

Does Chronic Obstructive Lung Disease Influence the Cognitive Function: Assessment Using a Driving Simulator and Other Cognitive Tests

TypeinterventionalSponsorSygehus LillebaeltRan2020 to 2023Enrolled102ConditionsChronic Obstructive Pulmonary DiseaseArmsdriving simulator
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Altered brain glucose metabolism and connectivity in young adults with obstructive sleep apnea.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristina Kock HansenDepartment of Medicine, University Hospital of Southern Denmark, Lillebaelt Hospital, Beriderbakken 4, Vejle, 7100, Denmark. kristina.kock.hansen2@rsyd.dk.ORCID 0000-0001-9564-958X
Anders LøkkeDepartment of Medicine, University Hospital of Southern Denmark, Lillebaelt Hospital, Beriderbakken 4, Vejle, 7100, Denmark.
Hanne Irene JensenDepartment of Regional Health Research, University of Southern Denmark, Odense, Denmark.
Eline Kirstine GantzhornDepartment of Medicine, University Hospital of Southern Denmark, Lillebaelt Hospital, Beriderbakken 4, Vejle, 7100, Denmark.
Ingeborg Farver-VestergaardDepartment of Medicine, University Hospital of Southern Denmark, Lillebaelt Hospital, Beriderbakken 4, Vejle, 7100, Denmark.
Ole HilbergDepartment of Medicine, University Hospital of Southern Denmark, Lillebaelt Hospital, Beriderbakken 4, Vejle, 7100, Denmark.

Funding

Chiesi Foundation Chiesi FoundationDanmarks Lungeforening Danmarks LungeforeningEva Merete Falck Crones Foundation Eva Merete Falck Crones FoundationSygehus Lillebælt Sygehus LillebæltWonges Foundation Wonges Foundation
6 · The paper itself

Abstract

purposeThis study aimed to examine the association between obstructive sleep apnea (OSA) and cognitive function in patients with severe chronic obstructive pulmonary disease (COPD).

methodsPatients with severe COPD, who had not previously been diagnosed with OSA, were recruited between January 2021 and January 2023. To evaluate cognitive function, the Montreal Cognitive Assessment (MoCA), a continuous reaction time test (CRT) and a driving simulator were used. OSA was identified using a CardioRespiratory Monitor (CRM). Cognitive tests were repeated for patients who were identified with and received treatment for OSA, to determine whether treatment improved cognitive function.

resultsIn total, 80 patients participated in the study and 50 patients (63%) were diagnosed with OSA, with or without nocturnal desaturation (ND), and six patients (8%) with ND only. Thirty-two patients (40%) had mild OSA and 18 (23%) had moderate/severe OSA. We found no statistically significant difference in the prevalence of cognitive impairment (CI) between patients with and without OSA and/or ND. However, a multiple regression analysis showed that patients with moderate/severe OSA had a significant lower CRT-index, indicating a decrease in attention and reaction time, compared to patients with mild OSA.

conclusionIn patients with COPD and OSA, the degree of CI may depend on the severity of OSA. The 23% prevalence of moderate/severe OSA emphasizes the importance of OSA screening in severe COPD. The study was registered at www. CLINICALTRIALS: gov in March 2020, with the identification number NCT04458038.

Indexed as

Cognitive DysfunctionPulmonary Disease, Chronic ObstructiveSleep Apnea, ObstructiveAgedCognitionFemaleHumansMaleMiddle AgedSeverity of Illness IndexChronic obstructive pulmonary diseaseCognitive functionCognitive impairmentNocturnal desaturationObstructive sleep apneaOverlap syndrome

Identifiers

PMID39673053
PMCPMC11645309

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.