ArticleBiophysical journal2025
Lipid demixing reduces energy barriers for high-curvature vesicle budding.
Article in Biophysical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The variational modulus density theory explains mechanical responses of cell membranes and membrane crosslinkers.Scientific reports · 2025Article
- Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs.Advanced healthcare materials · 2025Review
- Membrane fusion and budding.Biophysical journal · 2025Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Under standard physiological conditions, budding relies on asymmetries, including differences in leaflet composition, area, and osmotic conditions, and involves large curvature changes in nanoscale lipid vesicles. So far, the combined impact of asymmetry and high curvatures on budding has remained unknown. Here, using the continuum elastic theory, the budding pathway is detailed under realistic conditions. The model enables a quantitative description of the budding process and the budded state of both ideally and nonideally mixed lipid nanoscale vesicles. It shows that budding is less favored in smaller vesicles but that lipid demixing can significantly reduce its energy barrier, and yet high compositional deviations of more than 7% between the bud and vesicle only occur with phase separation on the bud.
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Registered trials
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