Evidence map›Paper›PMID 39673593›Full record

ReviewNeurochemical research2024

ALG13-Related Epilepsy: Current Insights and Future Research Directions.

Peng Gao, Haoran Chen, Yangyang Sun, Xin Qian, Tao Sun, Yuhan Fan, Jing Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurochemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. NovelHuman mutation · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peng Gao *Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Haoran Chen *Ningxia Key Laboratory of Cerebrocranial Diseases, The Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Yangyang Sun *Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Xin QianNingxia Key Laboratory of Cerebrocranial Diseases, The Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Tao SunDepartment of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China.
Yuhan FanGeneral Hospital of Ningxia Medical University, No. 804 of Shengli Street, Yinchuan, Ningxia Province, 750004, China.
Jing ZhangInstitute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Province, 750004, China. zhang_jing8523@126.com.

Funding

Key R&D projects of Ningxia Hui Autonomous Region 2020BEB04033National Natural Science Foundation of China (NSFC) 82001215Scientific Research Program of Ningxia Colleges and Universities CBSC-PA202402020004
6 · The paper itself

Abstract

The ALG13 gene encodes a subunit of the uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transferase enzyme, which plays a key role in the N-linked glycosylation pathway. This pathway involves the attachment of carbohydrate structures to asparagine (Asn) residues in proteins within the endoplasmic reticulum, by which N-glycosylated proteins produced participate a wide range of processes such as electrical gradients formation and neurotransmission. Mutations in the ALG13 gene have been identified as a causative factor for congenital disorders of glycosylation (CDG) and have been frequently associated with epilepsy in affected individuals. Several studies have demonstrated a strong correlation between abnormal N-glycosylation due to ALG13 deficiency and the onset of epilepsy. Despite these findings, the precise role of ALG13 in the pathogenesis of epilepsy remains unclear. This review provides a comprehensive overview of the current literature on ALG13-related disorders, with a focus on recent evidence regarding its role in epilepsy development and progression. Future research directions are also proposed to further elucidate the molecular mechanisms underlying this association.

Indexed as

EpilepsyAnimalsGlycosylationHumansMutationN-AcetylglucosaminyltransferasesALG13 protein, humanN-AcetylglucosaminyltransferasesALG13Congenital disorder in glycosylationEpilepsyGene mutationN-glycosylation

Identifiers

PMID39673593

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.