Evidence map›Paper›PMID 39674887›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2025

Antiviral and immunomodulatory effects of ouabain against congenital Zika syndrome model.

Deyse Cristina Madruga Carvalho, Tiffany Dunn, Rafael Kroon Campos, Jessica A Tierney, Florence Onyoni, Luiz Henrique Agra Cavalcante-Silva, Lindomar José Pena, Sandra Rodrigues-Mascarenhas, Ping Wu, Scott C Weaver

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deyse Cristina Madruga CarvalhoLaboratory of Immunobiotechnology, Biotechnology Center, Federal University of Paraiba (UFPB), João Pessoa 58051-900, Paraiba, Brazil; Department of Virology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), Recife 50740-465, Pernambuco, Brazil; Department of Neurobiology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA; Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.
Tiffany DunnDepartment of Neurobiology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.
Rafael Kroon CamposDepartment of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.
Jessica A TierneyDepartment of Neurobiology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.
Florence OnyoniDepartment of Neurobiology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA.
Luiz Henrique Agra Cavalcante-SilvaLaboratory of Immunobiotechnology, Biotechnology Center, Federal University of Paraiba (UFPB), João Pessoa 58051-900, Paraiba, Brazil; Medical Sciences and Nursing Complex, Federal University of Alagoas, Arapiraca, 57309-005, Brazil.
Lindomar José PenaDepartment of Virology, Aggeu Magalhães Institute (IAM), Oswaldo Cruz Foundation (Fiocruz), Recife 50740-465, Pernambuco, Brazil.
Sandra Rodrigues-MascarenhasLaboratory of Immunobiotechnology, Biotechnology Center, Federal University of Paraiba (UFPB), João Pessoa 58051-900, Paraiba, Brazil.
Ping WuDepartment of Neurobiology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA. Electronic address: piwu@utmb.edu.
Scott C WeaverDepartment of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA. Electronic address: sweaver@utmb.edu.

Funding

World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5M
Role of microglia in neural infectionR01NS125778 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Tian Wang, Ping Wu · 2022 to 2026
$2.5M
NIAID NIH HHS R24 AI120942NINDS NIH HHS R01 NS125778
6 · The paper itself

Abstract

Zika virus (ZIKV) is an arbovirus associated with neurological disorders accompanying congenital infections. With no vaccine or antiviral approved, there is an urgent need for the development of effective antiviral agents against ZIKV infection. We evaluated the anti-ZIKV and immunomodulatory activity of ouabain, a Na

Indexed as

Antiviral AgentsOuabainZika VirusZika Virus InfectionAnimalsDisease Models, AnimalFemaleHumansMiceNeural Stem CellsPlacentaPregnancyAntiviral AgentsOuabainarboviruscardiotonic steroidcongenital zika syndromeinflammationneural stem cellsZika virus

Identifiers

PMID39674887
PMCPMC11852665

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.