Evidence map›Paper›PMID 39674978›Full record

ArticleJournal of nephrology2025

Comparison between female kidney donors with prediabetes and without diabetes in blood pressure measurements, kidney and diabetes biomarkers: a prospective cohort study.

Mahdi Tarabeih, Wasef Na'amnih

Abstract readComparative Study
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Article in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Mahdi TarabeihSchool of Nursing Science, The Academic College of Tel Aviv-Yaffo, 64044, Tel Aviv, Israel.
Wasef Na'amnihSchool of Nursing Science, The Academic College of Tel Aviv-Yaffo, 64044, Tel Aviv, Israel. wasefnammnih@tauex.tau.ac.il.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA comprehensive evaluation of potential living kidney donors is crucial to ensure their short and long-term safety. We explored differences in kidney biochemical indicators, blood pressure measurements, and glucose control pre- and post-kidney donation between women with pre-diabetes and those with normal glucose levels.

methodsWe performed a prospective cohort study at West Bank and Gaza University hospitals between 2016 and 2022. Differences in sociodemographic and clinical factors that were collected from the participants' medical records between women with pre-diabetes and without diabetes, pre- and post-donation, were assessed using the chi-square test for categorical variables and the Mann-Whitney U test for variables with skewed distribution. Trained nurses performed anthropometric measurements and drew fasting blood samples at various time points from one year before donation to five years after donation.

resultsAltogether, 114 female kidney donors (57 with pre-diabetes) aged 27-45 years (median = 35.7, IQR = 5.6) were included in the study. The post-donation median Body Mass Index (BMI) remained higher in women with pre-diabetes (35.02) than in those without diabetes (29.34) five years after donation, (P < 0.001). The 24 h protein, diastolic, and systolic blood pressure levels were significantly higher among women with pre-diabetes than among those without diabetes five years after donation, (P < 0.001). The median estimated glomerular filtration rate (eGFR) was significantly lower in pre-diabetic women (78.2 ml/min/1.73 m

conclusionsPre-diabetic donors showed an increased risk of adverse outcomes, including hypertension, impaired oral glucose tolerance test, worsening kidney function, and proteinuria. Our findings underscore the importance of maintaining regular check-ups and follow-ups in particular in pre-diabetic kidney donors.

Indexed as

Blood PressureDiabetes MellitusKidney TransplantationLiving DonorsNephrectomyPrediabetic StateAdultBiomarkersBlood GlucoseFemaleGlomerular Filtration RateHumansKidneyMiddle AgedProspective StudiesBiomarkersBlood GlucoseDiabetesEnd-stage kidney diseaseKidney function declineLiving donors

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.