Evidence map›Paper›PMID 39674994›Full record

SynthesisInternational journal of colorectal disease2024

Genomic mosaicism in colorectal cancer and polyposis syndromes: a systematic review and meta-analysis.

Francisco Cezar Aquino de Moraes, Nayara Rozalem Moretti, Vitor Kendi Tsuchiya Sano, Cristiane Wen Tsing Ngan, Rommel Mario Rodríguez Burbano

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of colorectal disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francisco Cezar Aquino de MoraesFederal University of Pará, Belém, Pará, 66073-005, Brazil. francisco.cezar2205@gmail.com.ORCID http://orcid.org/0000-0003-0623-8135
Nayara Rozalem MorettiUniversity of Western São Paulo, Presidente Prudente, 19050-920, Brazil.ORCID http://orcid.org/0009-0005-9875-4904
Vitor Kendi Tsuchiya SanoFederal University of Acre, Rio Branco, Acre, 69920-900, Brazil.ORCID http://orcid.org/0000-0001-8317-1857
Cristiane Wen Tsing NganUniversity Anhembi Morumbi, Piracicaba, São Paulo, 13425-380, Brazil.ORCID http://orcid.org/0009-0000-7745-528X
Rommel Mario Rodríguez BurbanoOphir Loyola Hospital, Belém, Pará, 66063-240, Brazil.ORCID http://orcid.org/0000-0002-4872-234X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer (CRC) and polypoid syndromes are significant public health concerns, with somatic mosaicism playing a crucial role in their genetic diversity. This study aimed to investigate the prevalence and impact of somatic mosaicism in these conditions.

methodsA search was conducted using PubMed, Scopus, and Web of Sciences to identify studies evaluating mosaicism in patients with CRC or polyposis syndromes. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to determine prevalence rates. Statistical analyses were performed using R software 4.3.

resultsA total of 27 studies, encompassing 2272 patients, were included in the analysis. Of these, 108 patients exhibited somatic mosaicism, resulting in an overall prevalence of 8.79% (95% CI 5.1 to 14.70%, I

conclusionsOur findings support the growing recognition of mosaicism as a critical factor in CRC susceptibility and underscore the importance of incorporating mosaicism screening into routine genetic testing for at-risk patients.

Indexed as

Colorectal NeoplasmsMosaicismAdenomatous Polyposis ColiGenetic Predisposition to DiseaseGenomicsHumansMutationMutL Protein Homolog 1MutS Homolog 2 ProteinMLH1 protein, humanMSH2 protein, humanMutL Protein Homolog 1MutS Homolog 2 ProteinAPC mutationColorectal cancerMLH1MosaicismMSH2Polypoid syndromes

Identifiers

PMID39674994
PMCPMC11646957

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.