Evidence map›Paper›PMID 39675356›Full record

ArticleArquivos de neuro-psiquiatria2024

Association of interleukin 4 and MTHFR gene polymorphisms with distal symmetrical polyneuropathy in young diabetics.

Raquel Garcia Rocco da Silva, Marcelo A Costa Lima, Claudia de Melo Moura, Jorge Luiz Luescher, Ludmila Nascimento Rodrigues Campos, Daniel de Souza E Silva, Márcia Gonçalves Ribeiro

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Article in Arquivos de neuro-psiquiatria, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Raquel Garcia Rocco da SilvaUniversidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagão Gesteira, Rio de Janeiro RJ, Brazil.ORCID 0000-0002-5650-6815
Marcelo A Costa LimaUniversidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcântara Gomes, Laboratório de Genética Molecular Humana, Rio de Janeiro RJ, Brazil.ORCID 0000-0002-9629-6138
Claudia de Melo MouraUniversidade do Estado do Rio de Janeiro, Instituto de Biologia Roberto Alcântara Gomes, Laboratório de Genética Molecular Humana, Rio de Janeiro RJ, Brazil.ORCID 0009-0006-2743-6041
Jorge Luiz LuescherUniversidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagão Gesteira, Rio de Janeiro RJ, Brazil.ORCID 0000-0003-4272-6160
Ludmila Nascimento Rodrigues CamposUniversidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagão Gesteira, Rio de Janeiro RJ, Brazil.ORCID 0009-0002-5301-1590
Daniel de Souza E SilvaPontífica Universidade Católica do Rio de Janeiro, Departamento de Medicina e Saúde, Rio de Janeiro RJ, Brazil.ORCID 0000-0002-0196-3250
Márcia Gonçalves RibeiroUniversidade Federal do Rio de Janeiro, Instituto de Puericultura e Pediatria Martagão Gesteira, Rio de Janeiro RJ, Brazil.ORCID 0000-0001-8906-0189

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is believed that genetic factors play a role in the development and severity of neural injury among people with distal symmetrical polyneuropathy (DSP), because some genes are involved in specific biological pathways, acting in different ways in the pathogenic process.

objectiveTo identify potential associations involving the

methodsIn total, 70 children and adolescents with type-1 diabetes underwent a nerve conduction studie (NCS) of the sural nerve. Saliva samples were collected for DNA extraction and genotyping of the

resultsThe prevalence of DSP was 15.71%. The participants with DSP presented higher mean levels of glycated hemoglobin, triglycerides, total cholesterol, and low-density lipoprotein (LDL) (

conclusionIn the present study, we found no association involving the

Indexed as

Diabetes Mellitus, Type 1Diabetic NeuropathiesGenotypeInterleukin-4Methylenetetrahydrofolate Reductase (NADPH2)Polymorphism, GeneticAdolescentChildFemaleGenetic Predisposition to DiseaseHumansMaleNeural ConductionInterleukin-4Methylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, human

Identifiers

PMID39675356
PMCPMC11646667

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.