ArticleBMJ open2024
Effect of high-efficiency particulate air filter on children with asthma: a systematic review protocol of RCTs.
Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAsthma has been classified as a major non-communicable disease by the WHO. With the worsening air quality index worldwide, the burden of asthma has increased specifically in children. The focus of the management strategy of asthma has shifted from traditional pharmacological treatments towards non-pharmacological preventive and control therapy in recent decades. The use of high-efficiency particulate air (HEPA) filters is one of the methods to achieve that, despite extensive research, the efficacy of HEPA filters in this context of effectiveness and usage guidelines remains unclear. Our study aims to examine the effect of HEPA filters in (1) reducing clinical visits or hospital admissions or the number of exacerbation events, (2) reducing asthma symptoms, (3) increasing asthma symptom-free days, (4) reducing indoor particulate matter 2.5 levels for children with asthma aged 5-17 years and (5) improving quality of life.
methodsWe will conduct a systematic review using MEDLINE, Google Scholar and Scopus as databases, article selection is planned to be restricted to randomised controlled trials only (2002-2025). We are following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines developed specifically for the protocol(s). Two reviewers will screen the studies independently and assess study quality using the Cochrane Risk of Bias Tool for Randomised Trials, V.2. The results of outcome measure(s) will be summarised in tables. If the studies are sufficient, we will also perform a quantitative analysis by creating forest plots and subgroup analysis will be performed if required. Lastly, publication bias will be assessed using a funnel plot and Egger's test and reported accordingly. ETHICS AND DISSEMINATION: We will conduct a systematic review, therefore there is no need for a formal ethical review. After successful completion, our results will be published in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CR42024494949.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.