ArticleGut microbes
The microbiota metabolite, phloroglucinol, confers long-term protection against inflammation.
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In one paragraph
Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The core role of central nervous system in sepsis-related organ damage.Frontiers in immunology · 2025Pooled it
- Gut microbiota and immunometabolism in obesity.Gut microbes · 2026Review
- Metabolic Reprogramming-Driven Cardiovascular Immune Damage: From Glyco-Lipotoxicity and Epigenetic Memory to Multidimensional Cross-Organ Communication Networks.International journal of molecular sciences · 2026Review
- Multi-omics and artificial intelligence for precision drug discovery and potential clinical applications.Signal transduction and targeted therapy · 2026Review
- Beyond Antioxidants: The Microbial Metabolic Landscape of Anthocyanins and Their Downstream Health Implications.Nutrients · 2026Review
- Review
- Challenge Specific Modulation of Responses to Adjuvant-Induced Innate Immune Memory.Immunology · 2026Article
- TidyMass2: advancing LC-MS untargeted metabolomics through metabolite origin inference and metabolic feature-based functional module analysis.Nature communications · 2026Article
- Bioactive compounds as therapeutic modulators of metabolic syndrome: targeting inflammation and gut microbiota regulation.Frontiers in physiology · 2026Review
- Aryl hydrocarbon receptor: a potential target for natural products in the treatment of inflammatory bowel disease.Frontiers in immunology · 2026Review
- Reimagining AHR in Cancer: From Environmental Sensor to Novel Immunomodulatory Therapeutic Target.International journal of biological sciences · 2026Review
- Gut microbial Nordihydroguaiaretic acid suppresses macrophage pyroptosis to regulate epithelial homeostasis and inflammation.Gut microbes · 2025Article
- Memory in Misfire: The Gut Microbiome-Trained Immunity Circuit in Inflammatory Bowel Diseases.International journal of molecular sciences · 2025Review
- Physicochemical Properties, Antioxidant and Antibacterial Activities and Anti-Hepatocarcinogenic Effect and Potential Mechanism ofFoods (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors.
Janire CasteloCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Sarai Araujo-ArisCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Diego BarrialesCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Samuel Tanner PascoCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Iratxe SeoaneCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Ainize Peña-CearraCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Ainhoa PalaciosCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Carolina SimóMolecular Nutrition and Metabolism, Institute of Food Science Research (CIAL), Spanish National Research Council (CSIC), Madrid, Spain.
Virginia Garcia-CañasMolecular Nutrition and Metabolism, Institute of Food Science Research (CIAL), Spanish National Research Council (CSIC), Madrid, Spain.
Muthita KhamwongWürzburg Institute of Systems Immunology, Max-Planck Research Group at the Julius-Maximilians Universität, Würzburg, Germany.
Itziar Martín-RuizCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Monika Gonzalez-LopezCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Laura BarcenaCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
José Ezequiel Martín RodríguezCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
José Luís LavínApplied Mathematics Department - Bioinformatics Unit, NEIKER-BRTA, Derio, Spain.
Naiara GutiezCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Raquel MarcosDepartamento de Microbiología y Bioquímica, Instituto de Productos Lácteos de Asturias, CSIC, Villaviciosa, Spain.
Estibaliz AtondoCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Arantza CobelaCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Laura Plaza-VinuesaDepartamento de PRocesos Tecnológicos y Biotecnología, Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), CSIC, Madrid, Spain.
Adrián PlataCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Eneko Santos-FernandezCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Alberto Fernandez-TejadaCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Mari Carmen VillaránÁrea de Alimentación Saludable, Tecnalia-BRTA, Miñano, Spain.
José Miguel MancheñoDepartment of Crystallography and Structural Biology, Institute of Physical Chemistry Blas Cabrera (IQF), CSIC, Madrid, Spain.
Juana Maria FloresDepartment of Animal Medicine and Surgery, Veterinary Faculty, Universidad Complutense de Madrid, Madrid, Spain.
Ana María AransayCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Aize PellónCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Blanca de Las RivasDepartamento de PRocesos Tecnológicos y Biotecnología, Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), CSIC, Madrid, Spain.
Rosario MuñozDepartamento de PRocesos Tecnológicos y Biotecnología, Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN), CSIC, Madrid, Spain.
Abelardo MargollesDepartamento de Microbiología y Bioquímica, Instituto de Productos Lácteos de Asturias, CSIC, Villaviciosa, Spain.ORCID 0000-0003-2278-1816
Patricia Ruas-MadiedoDepartamento de Microbiología y Bioquímica, Instituto de Productos Lácteos de Asturias, CSIC, Villaviciosa, Spain.ORCID 0000-0001-6158-9320
Maria Victoria SelmaLaboratory of Food & Health, Research Group on Quality, Safety and Bioactivity of Plant Foods, CEBAS-CSIC, Murcia, Spain.
Mercedes Gomez de AgüeroWürzburg Institute of Systems Immunology, Max-Planck Research Group at the Julius-Maximilians Universität, Würzburg, Germany.
Leticia AbeciaCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Juan AnguitaCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Héctor RodríguezCIC bioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phloroglucinol is a key byproduct of gut microbial metabolism that has been widely used as a treatment for irritable bowel syndrome. Here, we demonstrate that phloroglucinol tempers macrophage responses to pro-inflammatory pathogens and stimuli.
Indexed as
Gastrointestinal MicrobiomeInflammationMice, Inbred C57BLPhloroglucinolReceptors, Aryl HydrocarbonAnimalsAnti-Inflammatory AgentsBasic Helix-Loop-Helix ProteinsDisease Models, AnimalImmunity, InnateInflammatory Bowel DiseasesMacrophagesMiceAhr protein, mouseAnti-Inflammatory AgentsBasic Helix-Loop-Helix ProteinsPhloroglucinolReceptors, Aryl Hydrocarboncentral trained immunityinflammationMicrobiota byproductsphenolic derivatives
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.