Evidence map›Paper›PMID 39676708›Full record

ArticleGut microbes

Abnormalities in gut virome signatures linked with cognitive impairment in older adults.

Adewale S James, Noorul A Adil, Dayna Goltz, Divyani Tangudu, Diptaraj S Chaudhari, Rohit Shukla, Vivek Kumar, Ambuj Kumar, Michal M Masternak, Peter Holland and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Adewale S JamesUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.ORCID 0000-0003-3276-8914
Noorul A AdilUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Dayna GoltzUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.ORCID 0000-0001-8794-0748
Divyani TanguduUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Diptaraj S ChaudhariUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Rohit ShuklaUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Vivek KumarUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Ambuj KumarResearch Methodology and Biostatistics, Department of Internal Medicine, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Michal M MasternakSchool of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA.
Peter HollandDepartment of Neuroscience, FAU Schmidt College of Medicine/i-Health FAU, Boca Raton, FL, USA.
Corinne LabyakDepartment of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, USA.
Adam GoldenSchool of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA.
Mariana DangioloSchool of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA.
Andrea Y ArikawaDepartment of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, USA.
Judyta KociolekDepartment of Neuroscience, FAU Schmidt College of Medicine/i-Health FAU, Boca Raton, FL, USA.
Amoy FraserSchool of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA.
Cynthia WilliamsSchool of Global Health Management and Informatics, University of Central Florida, Orlando, FL, USA.
Marc AgroninBehavioral Health, MIND Institute, Miami Jewish Health, Miami, FL, USA.
Mariolga AymatBehavioral Health, MIND Institute, Miami Jewish Health, Miami, FL, USA.
Shalini JainUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Hariom YadavUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, USA.ORCID 0000-0003-4504-1597

Funding

Repurposing of Metormin for Older Patients with HFpEFU01AG076928 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W, YADAV, HARIOM · 2022 to 2024
$2.3M
Gut microbiota-based biomarkers of Alzheimer's disease and its modulation by a ketogenic dietR56AG064075 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI YADAV, HARIOM · 2020 to 2021
$1.2M
Microbial therapy improves gut permeability to reduce cognitive decline and Alzheimer’s diseaseR01AG071762 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YADAV, HARIOM · 2024 to 2025
$753k
The role of gut microbiota in the efficacy of ketogenic diet to ameliorate Alzheimer's diseaseR21AG072379 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YADAV, HARIOM · 2021 to 2021
$429k
Saliva based protein markers for predicting the risk of cognitive decline and dementia in older adults.R21AG082164 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI JAIN, SHALINI · 2023 to 2024
$412k
Metformin and Alzheimer's disease: Underlying Mechanisms that Ameliorate ProgressionR56AG069676 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI YADAV, HARIOM · 2020 to 2020
$388k
NIA NIH HHS R01 AG071762NIA NIH HHS R21 AG072379NIA NIH HHS R21 AG082164NIA NIH HHS R56 AG064075NIA NIH HHS R56 AG069676NIA NIH HHS U01 AG076928
6 · The paper itself

Abstract

Multiple emerging lines of evidence indicate that the microbiome contributes to aging and cognitive health. However, the roles of distinct microbial components, such as viruses (virome) and their interactions with bacteria (bacteriome), as well as their metabolic pathways (metabolome) in relation to aging and cognitive function, remain poorly understood. Here, we present proof-of-concept results from a pilot study using datasets (

Indexed as

AgingBacteriaBacteriophagesCognitive DysfunctionGastrointestinal MicrobiomeViromeAgedAged, 80 and overFemaleHumansMaleMetabolomeMiddle AgedPilot ProjectsagingcognitiondementiagutmicrobiomephageVirome

Identifiers

PMID39676708
PMCPMC11651276

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.