ArticleWorld journal of diabetes2024
Shikonin protects mitochondria through the NFAT5/AMPK pathway for the treatment of diabetic wounds.
Article in World journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundShikonin is a natural remedy that is effective at treating diabetic wounds. NFAT5 is a potential therapeutic target for diabetes, and mitochondrial function is essential for wound healing. However, the relationship among Shikonin, NFAT5, and mitochondrial function has not been thoroughly studied. Here, we offer new perspectives on the advantages of shikonin for managing diabetes.
aimTo assess the therapeutic mechanism of shikonin in diabetic wounds, its relationship with NFAT5, and its protection of mitochondrial function.
methodsHypertonic cell and diabetic wound mouse models were established. NFAT5 expression was measured through western blotting and immunofluorescence,
resultsShikonin treatment preserved HaCaT cell viability, while significantly reducing cyclooxygenase-2 expression levels in a high-glucose environment (
conclusionShikonin protects mitochondria
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