Evidence map›Paper›PMID 39676815›Full record

ArticleWorld journal of diabetes2024

β-Arrestin-2 enhances endoplasmic reticulum stress-induced glomerular endothelial cell injury by activating transcription factor 6 in diabetic nephropathy.

Jiang Liu, Xiao-Yun Song, Xiu-Ting Li, Mu Yang, Fang Wang, Ying Han, Ying Jiang, Yu-Xin Lei, Miao Jiang, Wen Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. GPCR Biased Signaling in Cancer.Handbook of experimental pharmacology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiang LiuCenter for Gene and Immunotherapy, Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, China.
Xiao-Yun SongCenter for Gene and Immunotherapy, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, China.
Xiu-Ting LiMedical Device and Pharmaceutical Packaging Inspection, Shandong Institute of Medical Device and Pharmaceutical Packaging Inspection, Jinan 250101, Shandong Province, China.
Mu YangCenter for Gene and Immunotherapy, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, China.
Fang WangCenter of Animal, Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, China.
Ying HanCenter of Animal, Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, China.
Ying JiangCenter for Gene and Immunotherapy, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, China.
Yu-Xin LeiCenter for Gene and Immunotherapy, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, China.
Miao JiangClinical Skill Training Centre, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, China.
Wen ZhangCenter for Gene and Immunotherapy, Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, China.
Dong-Qi TangCenter for Gene and Immunotherapy, Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, Shandong Province, China. tangdq@sdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlomerular endothelial cell (GENC) injury is a characteristic of early-stage diabetic nephropathy (DN), and the investigation of potential therapeutic targets for preventing GENC injury is of clinical importance.

aimTo investigate the role of β-arrestin-2 in GENCs under DN conditions.

methodsEight-week-old C57BL/6J mice were intraperitoneally injected with streptozotocin to induce DN. GENCs were transfected with plasmids containing siRNA-β-arrestin-2, shRNA-activating transcription factor 6 (ATF6), pCDNA-β-arrestin-2, or pCDNA-ATF6. Additionally, adeno-associated virus (AAV) containing shRNA-β-arrestin-2 was administered

resultsThe upregulation of β-arrestin-2 was observed in patients with DN as well as in GENCs from DN mice. Knockdown of β-arrestin-2 reduced apoptosis in high glucose-treated GENCs, which was reversed by the overexpression of ATF6. Moreover, overexpression of β-arrestin-2 Led to the activation of endoplasmic reticulum (ER) stress and the apoptosis of GENCs which could be mitigated by silencing of ATF6. Furthermore, knockdown of β-arrestin-2 by the administration of AAV-shRNA-β-arrestin-2 alleviated renal injury in DN mice.

conclusionKnockdown of β-arrestin-2 prevents GENC apoptosis by inhibiting ATF6-mediated ER stress

Indexed as

Activating transcription factor 6Diabetic nephropathyEndoplasmic reticulum stressGlomerular endothelial cellβ-Arrestin-2

Identifiers

PMID39676815
PMCPMC11580586

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.