ReviewCureus2024
Exposure to Poly- and Perfluoroalkyl Substances During Pregnancy and Asthma in Childhood: A Systematic Review.
Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Current Status of Per- and Poly-Fluoroalkyl Substances (PFAS) Exposure on Lung Cell Biology and Pulmonary Outcomes along Human Health Risk Assessment Steps.Current allergy and asthma reports · 2026Review
- Developmental Toxicity of Photolithography-Relevant Per- and Polyfluoroalkyl Substances (PFAS) Reveals Concerns for Less-Studied Functional Groups.Environmental science & technology · 2026Article
- Association between prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and the incidence of infant and childhood respiratory infections: A systematic review.Medicine internationalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma is a chronic respiratory disease that has been increasing in prevalence among children globally. While genetic factors contribute to asthma risk, there are growing concerns about environmental exposures, such as poly- and perfluoroalkyl substances (PFAS), which may disrupt respiratory and immune development in the prenatal period. This systematic review aimed to assess the association between prenatal PFAS exposure and the development of asthma in childhood, integrating findings from epidemiological studies. A comprehensive literature search was conducted on Scopus, PubMed, and Google Scholar using predefined keywords. The review included prospective cohort studies examining prenatal PFAS exposure and asthma outcomes in children. The quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS). A total of 13 studies were included in the final analysis. The studies involved diverse countries/populations with over 21,000 mother-child pairs. Although some studies reported associations between specific PFAS compounds and asthma, most found no significant relationship between prenatal PFAS exposure and doctor-diagnosed asthma. The findings were inconsistent, with null or mixed results across studies. Despite mechanistic evidence suggesting that PFAS could contribute to asthma development, epidemiological data do not consistently support a link between prenatal exposure and childhood asthma. Further research with standardized exposure measurements and larger cohort studies is needed to clarify these associations.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.