Evidence map›Paper›PMID 39677621›Full record

ArticlebioRxiv : the preprint server for biology2024

Contact Lens Wear Alters Transcriptional Responses to

Naren G Kumar, Melinda R Grosser, Stephanie Wan, Daniel Schator, Eugene Ahn, Eric Jedel, Vincent Nieto, David J Evans, Suzanne M J Fleiszig

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Naren G KumarHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA USA.
Melinda R GrosserHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA USA.
Stephanie WanHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA USA.
Daniel SchatorHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA USA.
Eugene AhnHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA USA.
Eric JedelHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA USA.
Vincent NietoHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA USA.
David J EvansHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA USA.
Suzanne M J FleiszigHerbert Wertheim School of Optometry & Vision Science, University of California, Berkeley, CA USA.

Funding

Transient Receptor Potential Ion Channels and Corneal Defense Against Bacterial AdhesionR01EY030350 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Suzanne MJ FLEISZIG · 2019 to 2026
$3.0M
NEI NIH HHS R01 EY030350
6 · The paper itself

Abstract

Purpose: Healthy corneas resist colonization by virtually all microbes yet contact lens wear can predispose the cornea to sight-threatening infection with Methods: Male and female C57BL/6J mice were fitted with a contact lens on one eye for 24 h. After lens removal, corneas were immediately challenged for 4 h with Results: Prior lens wear profoundly altered the corneal response to Conclusion: Prior lens wear impacts corneal epithelium gene expression altering its responses to

Identifiers

PMID39677621
PMCPMC11643048

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.