Evidence map›Paper›PMID 39677660›Full record

ArticlebioRxiv : the preprint server for biology2024

Intracellular pocket conformations determine signaling efficacy through the

David A Cooper, Joseph DePaolo-Boisvert, Stanley A Nicholson, Barien Gad, David D L Minh

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

David A CooperDepartment of Chemistry, Illinois Institute of Technology, Chicago, Illinois 60616, United States.ORCID 0009-0002-3640-7278
Joseph DePaolo-BoisvertDepartment of Chemistry, Illinois Institute of Technology, Chicago, Illinois 60616, United States.
Stanley A NicholsonDepartment of Applied Mathematics, Illinois Institute of Technology, Chicago, Illinois 60616, United States.
Barien GadDepartment of Applied Mathematics, Illinois Institute of Technology, Chicago, Illinois 60616, United States.ORCID 0000-0001-6955-7972
David D L MinhDepartment of Chemistry, Illinois Institute of Technology, Chicago, Illinois 60616, United States.ORCID 0000-0002-4802-2618

Funding

NIGMS NIH HHS R01 GM127712
6 · The paper itself

Abstract

It has been challenging to determine how a ligand that binds to a receptor activates downstream signaling pathways and to predict the strength of signaling. The challenge is compounded by functional selectivity, in which a single ligand binding to a single receptor can activate multiple signaling pathways at different levels. Spectroscopic studies show that in the largest class of cell surface receptors, 7 transmembrane receptors (7TMRs), activation is associated with ligand-induced shifts in the equilibria of intracellular pocket conformations in the absence of transducer proteins. We hypothesized that signaling through the

Indexed as

7 transmembrane helix receptorActivation mechanismFunctional selectivityG protein coupled receptorSignaling efficacy

Identifiers

PMID39677660
PMCPMC11642773

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.