ArticleAmerican journal of translational research2024
Association of PTOV1 and Cyfra21-1 with neoadjuvant chemosensitivity in patients with lung adenocarcinoma.
Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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4 authors.
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Abstract
objectivesThis retrospective study mainly analyzed the relationship between prostate tumor overexpressed 1 (PTOV1) and cytokeratin 19 fragment (Cyfra21-1) and neoadjuvant chemosensitivity in patients with lung adenocarcinoma (LUAC).
methodsA total of 110 LUAC patients who received neoadjuvant chemotherapy (cisplatin 75 mg/m
resultsSignificant differences were observed between the chemoresistant and chemosensitive groups in age, distant metastasis, and tumor differentiation. The chemoresistant group showed significantly higher levels of PTOV1 and Cyfra21-1 compared to the chemosensitive group. Both PTOV1 and Cyfra21-1 were significantly correlated with neoadjuvant chemosensitivity, with an area under the curve of no less than 0.700 for predicting chemosensitivity in LUAC patients. Logistic regression analysis indicated that distant metastasis, differentiation status, PTOV1, and Cyfra21-1 were independent factors influencing neoadjuvant chemosensitivity in LUAC patients.
conclusionsPTOV1 and Cyfra21-1 are upregulated in LUAC patients who are resistant to neoadjuvant chemotherapy. Both markers not only have predictive value for chemosensitivity in these patients, but are also independent factors affecting neoadjuvant chemosensitivity.
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