Evidence map›Paper›PMID 39678980›Full record

ArticleIndian journal of microbiology2024

Enhanced Immune Responses Against

Chuanzhi Zhu, Qingde Song, Xinrong Li, Xiuyun He, Junli Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chuanzhi ZhuLaboratory of Molecular Biology, Beijing Key Laboratory for Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, 101149 China.
Qingde SongBeijing Key Laboratory of Organ Transplantation and Immunology Regulation, The Eighth Medical Centre, Chinese PLA General Hospital, Beijing, 100091 China.
Xinrong LiBeijing Key Laboratory of Organ Transplantation and Immunology Regulation, The Eighth Medical Centre, Chinese PLA General Hospital, Beijing, 100091 China.
Xiuyun HeBeijing Key Laboratory of Organ Transplantation and Immunology Regulation, The Eighth Medical Centre, Chinese PLA General Hospital, Beijing, 100091 China.
Junli LiBeijing Key Laboratory of Organ Transplantation and Immunology Regulation, The Eighth Medical Centre, Chinese PLA General Hospital, Beijing, 100091 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing challenge of drug-resistant tuberculosis (TB) calls for the development of innovative therapeutic strategies, highlighting the potential of adjunctive immunotherapies that are both cost-effective and safe. Host-directed therapy (HDT) using immunomodulators shows promise in enhancing treatment efficacy by modulating immune responses, thereby shortening the duration of therapy and reducing drug resistance risks. This study investigated the immunomodulatory potential of combining Heat-killed Bacillus Calmette-Guérin (hBCG) with a Squalene-based oil-in-Water Emulsion (SWE) adjuvant against TB. The therapeutic efficacy of the hBCG-SWE regimen was assessed in a guinea pig model infected with

Indexed as

Heat-killed BCGImmune responsesImmunomodulatorMycobacterium tuberculosisSqualene-in-Water Emulsion

Identifiers

PMID39678980
PMCPMC11645453

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.