ReviewFrontiers in pharmacology2024
Genotoxic and antigenotoxic medicinal plant extracts and their main phytochemicals: "A review".
Review in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Comparative Valorization of Amazonian Fruit Wastes Reveals Açaí Seeds as a Promising Source of Antibacterial and Antioxidant Compounds.Journal of food science · 2026Article
- Phytochemical Analysis and Bioevaluation ofAntioxidants (Basel, Switzerland) · 2026Article
- Comparative Action of Blue Food Colorants (Genipin, Patent Blue V, and Brilliant Blue FCF); Their Effect on Oxidative Stress in Human Plasma and Blood Platelets In Vitro.International journal of molecular sciences · 2026Article
- Phytochemical Profile and In Vivo Assessment of Toxicity and Anti-Inflammatory Activity ofPlants (Basel, Switzerland) · 2026Article
- Humic substances enhance the anti-cancer efficacy of standard therapies.Cell death discovery · 2026Article
- From Forestry By-Product to Functional Food Ingredient Innovation: Antiproliferative, Antimetastatic and Antiplasmodial Activities of Norway Spruce Sawdust Extract.Foods (Basel, Switzerland) · 2026Article
- Comparative phytochemical, antioxidant, and hemostatic studies of leaf and stem extracts ofFrontiers in molecular biosciences · 2026Article
- Screening of Cytotoxic and Genotoxic Activities of Subcritical Water Extracts fromMolecules (Basel, Switzerland) · 2025Article
- Article
- Metabolomic Profiling and In Vitro Evaluation of Cytotoxic, Genotoxic, and Antigenotoxic Effects ofBiomolecules · 2025Article
- Phytochemical Study, Cytotoxicity, and Genotoxicity of the Methanolic Extract ofPlants (Basel, Switzerland) · 2025Article
- Evaluation of Clastogenic and Aneugenic Action of Two Bio-Insecticides Using Allium Bioassay.Journal of xenobiotics · 2025Article
- Phytochemical nanoencapsulation and microfluidics drive gene and tumor microenvironment modulation.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many medicinal plant extracts have been proven to have significant health benefits. In contrast, research has shown that some medicinal plant extracts can be toxic, genotoxic, mutagenic, or carcinogenic. Therefore, evaluation of the genotoxicity effects of plant extracts that are used as traditional medicine is essential to ensure they are safe for use and in the search for new medication. This review summarizes 52 published studies on the genotoxicity of 28 plant extracts used in traditional medicine. A brief overview of the selected plant extracts, including, for example, their medicinal uses, pharmacological effects, and primary identified compounds, as well as plant parts used, the extraction method, genotoxic assay, and phytochemicals responsible for genotoxicity effect were provided. The genotoxicity effect of selected plant extracts in most of the reviewed articles was based on the experimental conditions. Among different reviewed studies, A total of 6 plant extracts showed no genotoxic effect, other 14 plant extracts showed either genotoxic or mutagenic effect and 14 plant extracts showed anti-genotoxic effect against different genotoxic induced agents. In addition, 4 plant extracts showed both genotoxic and non-genotoxic effects and 6 plant extracts showed both genotoxic and antigenotoxic effects. While some suggestions on the responsible compounds of the genotoxicity effects were proposed, the proposed responsible phytochemicals were not individually tested for the genotoxicity potential to confirm the findings. In addition, the mechanisms by which most plant extracts exert their genotoxicity effect remain unidentified. Therefore, more research on the genotoxicity of medicinal plant extracts and their genotoxicity mechanisms is required.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.