Evidence map›Paper›PMID 39680142›Full record

SynthesisMedical molecular morphology2025

Oral pemphigus vulgaris diagnostic characteristics and treatment: a systematic review.

Solimar Ribeiro Carlete Filho, Luana Amorim Morais da Silva, Caio Rodrigues Maia, Paulo Roberto de Andrade Santos, Pollianna Muniz Alves, Pedro Paulo de Andrade Santos

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Medical molecular morphology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Solimar Ribeiro Carlete FilhoFederal University of Paraná (UFPR), Curitiba, PR, Brazil.
Luana Amorim Morais da SilvaFederal University of Rio Grande Do Norte (UFRN), Natal, RN, Brazil.
Caio Rodrigues MaiaFederal University of Rio Grande Do Norte (UFRN), Natal, RN, Brazil.
Paulo Roberto de Andrade SantosDepartment of Fundamentals and Policies of Education, Federal University of Rio Grande Do Norte (UFRN), Natal, RN, Brazil.
Pollianna Muniz AlvesDepartment of Dentistry, State University of Paraíba (UEPB), Campina Grande, PB, Brazil.
Pedro Paulo de Andrade SantosBiosciences Center, Department of Morphology, Federal University of Rio Grande Do Norte (UFRN), Campus Universitário, Lagoa Nova, Natal, RN, CEP 59072-970, Brazil. pedro.paulo.santos@ufrn.br.ORCID http://orcid.org/0000-0002-5793-3886

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pemphigus vulgaris (PV) is a rare, potentially fatal, immune-mediated chronic disease characterized by the presence of bullous intraepithelial lesions on mucous membranes and skin. This study aimed to perform a systematic literature review covering PV clinical and histopathological aspects and treatment. The literature searches were carried out in the Pubmed, Periódicos Capes, Scopus, Science Direct, Web of Science and Scielo databases. Articles in English or Spanish published from 2000 to 2022 comprising case reports, case series and literature reviews with case report were included. After the analyses, 21 articles were selected. PV generally presents in the third to sixth decades of life and exhibits no gender predilection. The disease manifests itself clinically through irregular and painful blisters that rupture, resulting in erosion and ulceration areas. Histopathologically, the presence of an intraepithelial cleft located above the basal layer and acantholysis are observed. Standard treatment encompasses systemic and topical corticosteroids, with prednisolone being widely employed. Management consists of a remission induction phase and a maintenance phase. An early and accurate diagnosis is paramount to quickly initiate treatment, resulting in more favorable prognoses, as the choice of treatment and responses depend on the severity of the disease. Registered at the International Prospective Register of Systematic Reviews (PROSPERO): Number CRD42024497313.

Indexed as

Mouth DiseasesPemphigusHumansDiagnosisOral cavityPemphigusTreatment

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.