ArticleInterdisciplinary cardiovascular and thoracic surgery2024
Feasibility of 4D-flow CMR for haemodynamic characterization in hypertrophic cardiomyopathy after septal myectomy with and without anterior mitral valve leaflet extension.
Article in Interdisciplinary cardiovascular and thoracic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Multimodality Imaging in Apical Hypertrophic Cardiomyopathy: Can Echocardiography Learn from Cardiac Magnetic Resonance?Diagnostics (Basel, Switzerland) · 2025Review
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8 authors.
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Abstract
objectivesThe common surgical treatment in patients with obstructive hypertrophic cardiomyopathy is septal myectomy. This involves resection of a segment of the myocardial septum and can be performed with and without concomitant anterior mitral valve leaflet extension (AMVLE). While both approaches have satisfying clinical outcomes, there is a lack of data regarding the added value of concomitant AMVLE. In particular, their impact on postoperative haemodynamics remains unexplored. Therefore, we conducted a study to assess the feasibility of utilizing four-dimensional-flow cardiac magnetic resonance imaging (4D-flow cardiac magnetic resonance imaging (CMR)) to investigate postoperative haemodynamic differences among both surgical approaches.
methodsIn this feasibility study, nine subjects underwent 4D-flow CMR evaluation, including three patients who underwent isolated myectomy, three patients with myectomy + AMVLE and three healthy controls. Primary end-points were aortic wall shear stress, left ventricular outflow tract (LVOT) peak velocity and peak kinetic energy in the LVOT and ascending aorta.
resultsResults showed that patients who underwent myectomy with concomitant AMVLE exhibited (i) lower aortic wall shear stress (-21.2%), (ii) lower LVOT peak velocity (-6.3%), (iii) higher kinetic energy in the LVOT (+10.8%) and (iv) lower kinetic energy in the ascending aorta (-28.8%) compared to patients who underwent isolated myectomy.
conclusionsPatients undergoing additional AMVLE exhibited a better trend towards the haemodynamic reference values from healthy controls compared to patients undergoing isolated myectomy. Our findings underscore the feasibility of 4D-flow CMR to assess postoperative haemodynamic differences in hypertrophic cardiomyopathy patients undergoing different surgical approaches. This highlights the potential of 4D-flow CMR to compare surgical strategies based on postoperative haemodynamics. CLINICAL REGISTRATION NUMBER: Dutch National Medical Ethics Committee, registration number 2022.0078.
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