Evidence map›Paper›PMID 39681336›Full record

ReviewAnnual review of public health2025

Quantification of Epigenetic Aging in Public Health.

Cynthia D J Kusters, Steve Horvath

Abstract readReview
In one paragraph

Review in Annual review of public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. How does life course exposure to contextual disadvantage accelerate biological aging? The role of psychological symptoms.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
  14. Observational
  15. Frailty in lung transplant recipients is associated with anemia and telomere dysfunction but independent of epigenetic age.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cynthia D J KustersDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California, USA; email: ckusters@ucla.edu.
Steve HorvathAltos Labs, Cambridge, United Kingdom; email: shorvath@altoslabs.com.

Funding

Validation and optimization of epigenetic clocksU01AG060908 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2018 to 2022
$3.4M
Biological pathways linking sleep health to Alzheimers disease and cognitive declineK01AG081542 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Cynthia Diana Johanna Kusters · 2024 to 2026
$388k
NIA NIH HHS K01 AG081542NIA NIH HHS U01 AG060908
6 · The paper itself

Abstract

Estimators of biological age hold promise for use in preventive medicine, for early detection of chronic conditions, and for monitoring the effectiveness of interventions aimed at improving population health. Among the promising biomarkers in this field are DNA methylation-based biomarkers, commonly referred to as epigenetic clocks. This review provides a survey of these clocks, with an emphasis on second-generation clocks that predict human morbidity and mortality. It explores the validity of epigenetic clocks when considering factors such as race, sex differences, lifestyle, and environmental influences. Furthermore, the review addresses the current challenges and limitations in this research area.

Indexed as

AgingEpigenesis, GeneticPublic HealthBiomarkersDNA MethylationFemaleHumansLife StyleMaleBiomarkersagingepigenetic ageepigenetic clockhuman studies

Identifiers

PMID39681336
PMCPMC12180540

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.