Evidence map›Paper›PMID 39681752›Full record

Trial reportClinical oral investigations2024

Effectiveness of intra-oral botulinum toxin injection in comparison to the extra-oral approach on pain and quality of life in patients with myofascial pain: a randomized clinical trial.

Alshaimaa Ahmed Shabaan, Islam Kassem, Inass Aboulmagd, Islam A Amer, Ahmed Shaaban, Mohamed Abd-El-Ghafour, Shaimaa Mohsen Refahee

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05673655 (Evaluation of Ultrasound Sonography Intraoral Guided Injection of Botulinum Toxin in Masseter Muscle), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05673655 phase2unknown statusnot on this map

Evaluation of Ultrasound Sonography Intraoral Guided Injection of Botulinum Toxin in Masseter Muscle

TypeinterventionalSponsorFayoum UniversityRan2022 to 2023Enrolled40ConditionsMyofacial PainArmsintraoral trigger point injection by botox, transcutaneous trigger point injection by botox
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alshaimaa Ahmed ShabaanDepartment of Oral & Maxillofacial Surgery, Faculty of Dentistry, Fayoum University, Fayoum, Egypt.ORCID https://orcid.org/0000-0002-6105-4999
Islam KassemConsultant Oral and Maxillofacial Surgery, Main University Hospital, Alexandria University, Alexandria, Egypt.ORCID https://orcid.org/0000-0002-1710-7862
Inass AboulmagdOral & Maxillofacial Radiology Department, Faculty of Dentistry, Fayoum University, Fayoum, Egypt.ORCID https://orcid.org/0000-0003-0737-1384
Islam A AmerMaxillofacial, Head and Neck Surgery Unit, General surgery Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
Ahmed ShaabanProsthodontic Department, Faculty of Dentistry, Future University, Cairo, Egypt.
Mohamed Abd-El-GhafourDepartment of Orthodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-0870-1472
Shaimaa Mohsen RefaheeOral and Maxillofacial Surgery Department, Faculty of Dentistry, Fayoum University, Fayoum, Egypt. smr11@fayoum.edu.eg.ORCID https://orcid.org/0000-0002-7550-1913

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate and compare the effectiveness of the ultrasound-guided intra-oral and extra-oral transcutaneous injection techniques on the clinical outcome variables in patients with myofascial trigger points within the masseter muscle. MATERIALS AND

methodsThis prospective randomized trial included 42 patients diagnosed with myofascial pain. Patients were randomly allocated into one of two groups based on the technique of trigger point injection: intraoral and extraoral injection technique groups. Each trigger point was injected with 0.1 ml of botulinum-A toxin guided by ultrasound. Pain intensity, mouth opening, and patient quality of life were monitored six months post-injection.

resultsThe pain scores were significantly higher in the extraoral group during all follow-up assessments, whereas the MMO was considerably greater in the intraoral group up to three months of follow-up (p < 0.008). However, the difference in MMO ceased to be statistically non-significant after six months of follow-up (p = 0.927). Additionally, the patient's quality of life score was significantly higher in the intraoral group compared to the extraoral group (p < 0.001) at both the three- and six-month follow-ups.

conclusionThe intraoral injection technique might be an effective treatment modality for myofascial trigger points in the masseter muscle. It produces pain relief, increases mouth opening, and enhances the overall quality of life compared to the extraoral injection technique. CLINICAL SIGNIFICANCE: The intraoral injection technique for myofascial trigger points is more effective than the extraoral technique; it reduces the need for additional injections, saves money, and enhances patients' quality of life.

trial registrationClinicaltrials.gov (NCT05673655).

Indexed as

Botulinum Toxins, Type AMasseter MuscleMyofascial Pain SyndromesNeuromuscular AgentsQuality of LifeAdultFemaleHumansInjections, IntramuscularMaleMiddle AgedPain MeasurementProspective StudiesTreatment OutcomeTrigger PointsUltrasonography, InterventionalBotulinum Toxins, Type ANeuromuscular AgentsBotulinumMyofascial painTrigger pointUltrasonography-guided injection

Identifiers

PMID39681752
PMCPMC11649703

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.