Evidence map›Paper›PMID 39682078›Full record

ArticleCell proliferation2025

CTCF Point Mutation at R567 Disrupts Mouse Heart Development via 3D Genome Rearrangement and Transcription Dysregulation.

Huawei Ren, Hongxin Zhong, Jie Zhang, Yuli Lu, Gongcheng Hu, Weixun Duan, Ning Ma, Hongjie Yao

Abstract read
In one paragraph

Article in Cell proliferation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huawei RenCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China.
Hongxin ZhongState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Jie ZhangState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Yuli LuState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Gongcheng HuDepartment of Basic Research, Guangzhou National Laboratory, Guangzhou, China.
Weixun DuanDepartment of Cardiovascular Surgery, Xijing Hospital, Xi'an, China.
Ning MaSchool of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Hongjie YaoState Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Funding

Guangzhou Key R&D Program 2023B03J1230Key R&D Program of Shaanxi Province 2022ZDLSF02-01National Key R&D Program of China 2021YFA1100300National Natural Science Foundation of China 31925009National Natural Science Foundation of China 32300477National Natural Science Foundation of China 32430016National Natural Science Foundation of China U21A20195Special Support Project for Basic Research of Shaanxi Province 2023JC-XJ-11
6 · The paper itself

Abstract

CTCF plays a vital role in shaping chromatin structure and regulating gene expression. Clinical studies have associated CTCF mutations with congenital developmental abnormalities, including congenital cardiomyopathy. In this study, we investigated the impact of the homozygous CTCF-R567W (Ctcf

Indexed as

CCCTC-Binding FactorHeartPoint MutationTranscription, GeneticAnimalsGene Expression Regulation, DevelopmentalMiceCCCTC-Binding FactorCtcf protein, mouse3D chromatin architectureCTCF mutationembryonic heart developmentmousetranscriptional regulation

Identifiers

PMID39682078
PMCPMC11969252

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.