Evidence map›Paper›PMID 39682159›Full record

ArticleCancers2024

Direct Interaction Between CD34

Rémi Safi, Tala Mohsen-Kanson, Farah Kouzi, Jamal El-Saghir, Vera Dermesrobian, Inés Zugasti, Kazem Zibara, Pablo Menéndez, Hiba El Hajj, Marwan El-Sabban

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rémi SafiDepartment of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut 1107, Lebanon.ORCID 0000-0002-1697-872X
Tala Mohsen-KansonFaculty of Science, Lebanese University, Zahle 1801, Lebanon.
Farah KouziFaculty of Science, Lebanese University, Zahle 1801, Lebanon.
Jamal El-SaghirDepartment of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut 1107, Lebanon.
Vera DermesrobianDepartment of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut 1107, Lebanon.
Inés ZugastiDepartment of Hematology, Hospital Clínic Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-7666-5055
Kazem ZibaraFaculty of Science, Lebanese University, Zahle 1801, Lebanon.ORCID 0000-0002-9887-072X
Pablo MenéndezJosep Carreras Leukemia Research Institute, 08916 Barcelona, Spain.
Hiba El HajjDepartment of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut 1107, Lebanon.ORCID 0000-0002-1069-0477
Marwan El-SabbanDepartment of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Beirut 1107, Lebanon.

Funding

American University of Beirut MPP and URBLebanese National Council for Scientific Research CNRS
6 · The paper itself

Abstract

BACKGROUND/

objectivesA specialized microenvironment in the bone marrow, composed of stromal cells including mesenchymal stem cells (MSCs), supports hematopoietic stem cell (HSC) self-renewal, and differentiation bands play an important role in leukemia development and progression. The reciprocal direct interaction between MSCs and CD34

methodsHere, we established a direct co-culture model between MSCs and CD34

resultsFollowing MSCs-CD34

conclusionsIn conclusion, under physiological conditions, connexin 43 and N-Cadherin interaction preserves stemness of both CD34

Indexed as

acute myeloid leukemiabone marrowCD34+ hematopoietic stem cellsconnexin 43gap junctionheterocellular interactionmesenchymal stem cellsmicroenvironmentN-Cadherin

Identifiers

PMID39682159
PMCPMC11640414

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.