Evidence map›Paper›PMID 39682732›Full record

ArticleCells2024

Alginate vs. Hyaluronic Acid as Carriers for Nucleus Pulposus Cells: A Study on Regenerative Outcomes in Disc Degeneration.

Shota Ogasawara, Jordy Schol, Daisuke Sakai, Takayuki Warita, Takano Susumu, Yoshihiko Nakamura, Kosuke Sako, Shota Tamagawa, Erika Matsushita, Hazuki Soma and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shota OgasawaraDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Jordy ScholDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0001-5489-2591
Daisuke SakaiDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0003-4189-9270
Takayuki WaritaTUNZ Pharma Corporation, Osaka 541-0046, Japan.
Takano SusumuDepartment of Radiology, Tokai University Hospital, 143 Shimokasuya, Isehara 259-1193, Japan.
Yoshihiko NakamuraTUNZ Pharma Corporation, Osaka 541-0046, Japan.
Kosuke SakoDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Shota TamagawaDepartment of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.ORCID 0000-0002-5384-8158
Erika MatsushitaDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.
Hazuki SomaTUNZ Pharma Corporation, Osaka 541-0046, Japan.
Masato SatoDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0003-4049-7325
Masahiko WatanabeDepartment of Orthopedic Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara 259-1193, Japan.ORCID 0000-0001-9038-0446

Funding

the Japanese Agency for Medical Research and Development (AMED) JP23ym0126124TUNZ Pharma Corporation
6 · The paper itself

Abstract

Intervertebral disc degeneration is a leading cause of chronic low back pain, affecting millions globally. Regenerative medicine, particularly cell-based therapies, presents a promising therapeutic strategy. This study evaluates the comparative efficacy of two biomaterials-hyaluronic acid (HA) and alginate-as carriers for nucleus pulposus (NP) cell transplantation in a beagle model of induced disc degeneration. NP cells were isolated, cultured, and injected with either HA or alginate into degenerated discs, with saline and non-cell-loaded carriers used as controls. Disc height index, T2-weighted MRI, and histological analyses were conducted over a 12-week follow-up period to assess reparative outcomes. Imaging revealed that both carrier and cell-loaded treatments improved outcomes compared to degenerative controls, with cell-loaded carriers consistently outperforming carrier-only treated discs. Histological assessments supported these findings, showing trends toward extracellular matrix restoration in both treatment groups. While both biomaterials demonstrated reparative potential, HA showed greater consistency in supporting NP cells in promoting disc regeneration. These results underscore HA's potential as a superior carrier for NP cell-based therapies in addressing disc degeneration.

Indexed as

AlginatesHyaluronic AcidIntervertebral Disc DegenerationNucleus PulposusRegenerationAnimalsDogsAlginatesHyaluronic Acidalginateanimal modelback painbiomaterialscell therapydisc degenerationhyaluronic acidintervertebral disc

Identifiers

PMID39682732
PMCPMC11639827

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.