Evidence mapPaperPMID 39683371Full record

Observational studyNutrients2024

The Effectiveness and Safety of a Nutraceutical Combination in Overweight Patients with Metabolic Syndrome.

Lucilla Ricottini, Sabrina Basciani, Maria Letizia Spizzichini, Domenico de Mattia, Manuela Coniglio-Iannuzzi Delle Noci, Sasha Sorrentino, Maurizio Nordio

Abstract readObservational Study
In one paragraph

Observational study in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lucilla RicottiniSinergheia Clinical Center, 00192 Rome, Italy.
Sabrina BascianiDepartment of Experimental Medicine, University "Sapienza", 00161 Rome, Italy.
Maria Letizia SpizzichiniDepartment of Experimental Medicine, University "Sapienza", 00161 Rome, Italy.
Domenico de MattiaDe Mattia Center for Nutrition and Obesity, 70124 Bari, Italy.
Manuela Coniglio-Iannuzzi Delle NociDelle Noci Multy Specialty Center, 70124 Bari, Italy.
Sasha SorrentinoVilla Brasini Medical Center, 20100 Milan, Italy.
Maurizio NordioDepartment of Experimental Medicine, University "Sapienza", 00161 Rome, Italy.ORCID 0000-0001-6820-2512

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of the present study was to evaluate the effectiveness and safety of a nutraceutical combination given to insulin-resistant overweight patients with altered lipid profiles. To this end, an observational study was designed in which 74 individuals (50 females and 24 males) underwent an observational period of 3 months.

methodsDuring this time, a specific nutraceutical combination containing myo-inositol, glycine,

resultsAfter the 3-month period, the obtained data revealed that insulin levels significantly decreased with respect to the baseline, while glucose levels exhibited a trend towards lower concentrations, which was not significant. In addition, HOMA-IR index, body weight, BMI, and abdominal circumference values all decreased significantly. Regarding lipid profiles, the data obtained before and after the 3-month period showed statistically significant decreases in concentrations of total cholesterol, LDL cholesterol, and triglyceride, as well as a small but statistically significant concomitant increase in HDL cholesterol.

conclusionsThus, on the basis of these data, it may be stated that the specific nutraceutical combination used in the present study significantly ameliorated a number of metabolic parameters without measurable side effects. The efficacy and safety of the product were, therefore, confirmed in our group of patients.

Indexed as

Dietary SupplementsMetabolic SyndromeOverweightAdultBlood GlucoseBody Mass IndexCholesterol, HDLCholesterol, LDLFemaleGlycineHumansInositolInsulinInsulin ResistanceLipidsMaleBlood GlucoseCholesterol, HDLCholesterol, LDLGlycineInositolInsulinLipidspicolinic acidPicolinic AcidsThioctic AcidTriglyceridesinsulin resistancemetabolic dysfunctionnutraceuticalsoverweight

Identifiers

PMID39683371
PMCPMC11643896

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.