Evidence map›Paper›PMID 39683613›Full record

ArticleNutrients2024

Functional Modulation of Gut Microbiota and Blood Parameters in Diabetic Rats Following Dietary Intervention with Free or Immobilized

Ioanna Prapa, Amalia E Yanni, Vasiliki Kompoura, Gregoria Mitropoulou, Panayiotis Panas, Nikolaos Kostomitsopoulos, Yiannis Kourkoutas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Assessment of ImmobilizedFoods (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ioanna PrapaLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-0280-4443
Amalia E YanniLaboratory of Chemistry, Biochemistry, Physical Chemistry of Foods, Department of Nutrition and Dietetics, Harokopio University of Athens, 17671 Athens, Greece.ORCID 0000-0001-7984-7025
Vasiliki KompouraLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-0880-0275
Gregoria MitropoulouLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Panayiotis PanasQLC, N.E.O. Patron-Athinon 57, 26442 Patras, Greece.ORCID 0000-0002-5008-5255
Nikolaos KostomitsopoulosLaboratory Animal Facility, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.ORCID 0000-0003-4787-5106
Yiannis KourkoutasLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis, Greece.ORCID 0000-0003-2842-7666

Funding

Greece and the European Union (European Social Fund- ESF) Operational Pro-gramme "Human Resources Development, Education and Lifelong Learning 2014-2020" in the context of the project "Strengthening Human Resources Research Potential via Doctorate Re-search - 2nd Cycle" (MIS 5000432)
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe gut microbiota is linked to the pathogenesis of type 1 diabetes mellitus (T1DM), while supplementation with probiotics may result in positive alterations in the composition of the gut microbiome. This research aimed to map the changes in the gut microbiome and blood markers of streptozotocin-induced diabetic rats after a dietary intervention with free or immobilized cells of the presumptive probiotic

methodsTwenty-four male Wistar rats were studied and divided into four groups (healthy or diabetic) which received the free or the immobilized

resultsThe diabetic rats exhibited an elevated concentration of HDL-c, while the inflammatory IL-1β levels were significantly lower in the diabetic animals that received the immobilized cells compared to the group that received the free cells. The dietary intervention with immobilized cells led to decreased counts of fecal staphylococci and enterococci in the diabetic animals, while the diet with both free and immobilized

conclusionsDietary supplementation with

Indexed as

Diabetes Mellitus, ExperimentalFecesGastrointestinal MicrobiomeNutsPediococcus acidilacticiPistaciaProbioticsRats, WistarAnimalsMaleRatscell immobilizationgut microbiomeHDL-cIL-1βPediococcus acidilacticipistachioprobioticstype 1 diabetes mellitus

Identifiers

PMID39683613
PMCPMC11644729

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.