Evidence map›Paper›PMID 39683626›Full record

ArticleNutrients2024

Evaluation of the Leaves and Seeds of Cucurbitaceae Plants as a New Source of Bioactive Compounds for Colorectal Cancer Prevention and Treatment.

Mercedes Peña, Ana Guzmán, Cristina Mesas, Jesús M Porres, Rosario Martínez, Francisco Bermúdez, Consolación Melguizo, Laura Cabeza, Jose Prados

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mercedes PeñaInstitute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain.ORCID 0000-0001-5697-2261
Ana GuzmánCellbitec S.L., Scientific Headquarters of the Almeria Technology Park, University of Almeria, 04128 Almeria, Spain.ORCID 0000-0003-2727-8793
Cristina MesasInstitute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain.
Jesús M PorresDepartment of Physiology, Institute of Nutrition and Food Technology (INyTA), Biomedical Research Centre (CIBM), Sport and Health Research Institute (IMUDS), University of Granada, 18016 Granada, Spain.ORCID 0000-0001-5657-0764
Rosario MartínezDepartment of Physiology, Institute of Nutrition and Food Technology (INyTA), Biomedical Research Centre (CIBM), Sport and Health Research Institute (IMUDS), University of Granada, 18016 Granada, Spain.ORCID 0000-0003-2032-1621
Francisco BermúdezCellbitec S.L., Scientific Headquarters of the Almeria Technology Park, University of Almeria, 04128 Almeria, Spain.ORCID 0000-0002-0520-6740
Consolación MelguizoInstitute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain.ORCID 0000-0003-3990-806X
Laura CabezaInstitute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain.
Jose PradosInstitute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, 18100 Granada, Spain.ORCID 0000-0003-4303-7746

Funding

Spanish Ministry of Science, Innovation, and Universities RTC2019-006870-1
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe Cucurbitaceae family represents an important source of bioactive compounds with antioxidant, antimicrobial, anti-inflammatory and antitumor activities. This study aims to investigate the potential application of Cucurbitaceae leaves and seed extracts to prevent and treat colorectal cancer (CRC).

methodsFour extracts (ethanol extracts and protein extracts and hydrolysates) from the leaves and seeds of cucurbits were tested in T-84, HCT-15 and HT-29 CRC cells. The antitumor, antiangiogenic, antioxidant and chemopreventive potentials and bioactive composition of the active extracts were characterized.

resultsCold ethanolic extracts from the leaves and seeds of two interspecific

conclusionsExtracts from leaves the and seeds of two interspecific

Indexed as

Antineoplastic Agents, PhytogenicColorectal NeoplasmsPlant ExtractsPlant LeavesSeedsAntioxidantsApoptosisCell Line, TumorCell ProliferationCucurbitaceaeHT29 CellsHumansAntineoplastic Agents, PhytogenicAntioxidantsPlant Extractsantiangiogenicantioxidantantitumorchemopreventivecolorectal cancerCucurbitacucurbitaceaeextracts

Identifiers

PMID39683626
PMCPMC11644257

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.