ArticleMolecules (Basel, Switzerland)2024
Thermooxidation of Four Sartans: Kinetic Analysis Based on Thermo-Gravimetric Data.
Adriana Ledeţi, Bianca Baul, Amalia Ridichie, Denisa Ivan, Titus Vlase, Carmen Tomoroga, Anca Dragomirescu, Gabriela Vlase, Răzvan Adrian Bertici, Dana Emilia Man and 1 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
11 authors.
Adriana LedeţiAdvanced Instrumental Screening Center, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.ORCID 0000-0002-3462-1863 Bianca BaulFaculty of Industrial Chemistry and Environmental Engineering, University Politehnica Timisoara, 2 Victoriei Square, 300006 Timisoara, Romania.
Amalia RidichieAdvanced Instrumental Screening Center, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.ORCID 0009-0004-3921-2518 Denisa IvanAdvanced Instrumental Screening Center, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.ORCID 0000-0003-1211-8981 Titus VlaseResearch Centre for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115 Timisoara, Romania.ORCID 0000-0002-7480-7486 Carmen TomorogaAdvanced Instrumental Screening Center, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Anca DragomirescuAdvanced Instrumental Screening Center, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Gabriela VlaseResearch Centre for Thermal Analysis in Environmental Problems, West University of Timisoara, Pestalozzi Street 16, 300115 Timisoara, Romania.ORCID 0000-0002-1307-7010 Răzvan Adrian BerticiFaculty of Medicine, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Dana Emilia ManFaculty of Medicine, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.ORCID 0000-0001-6585-0004 Ionuţ LedeţiAdvanced Instrumental Screening Center, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2 Eftimie Murgu Square, 300041 Timisoara, Romania.ORCID 0000-0001-7603-9700 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Angiotensin II receptor antagonists are tetrazole derivatives used in the treatment of high blood pressure, and are also indicated for the treatment of heart failure (NYHA class II-IV). They are used alone or in combination with other classes of antihypertensives or diuretics for the effective management of high blood pressure. In this study, we aim to evaluate the thermal stability and degradation kinetics for the principal compounds used in therapy from this class, namely telmisartan, valsartan, olmesartan medoxomil, and losartan potassium. To obtain the thermoanalytical data for the kinetic investigations, the TG and DTG curves were registered at five different heating rates (β = 2, 4, 6, 8, and 10 °C min
Indexed as
LosartanValsartanAngiotensin Receptor AntagonistsAntihypertensive AgentsDrug StabilityKineticsOlmesartan MedoxomilOxidation-ReductionTelmisartanTetrazolesThermogravimetryAngiotensin Receptor AntagonistsAntihypertensive AgentsLosartanOlmesartan MedoxomilTelmisartanTetrazolesValsartanangiotensin II receptor antagonistskinetic analysissartanthermal stability
Identifiers
PMID39683686
PMCPMC11643681
What Socratic holds
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