Evidence map›Paper›PMID 39683852›Full record

ArticleMolecules (Basel, Switzerland)2024

Bioguided Identification of Polymethoxyflavones as Novel Vascular Ca

Anna Ramunno, Rosa Maria Vitale, Pietro Amodeo, Carlo Crescenzi, Alice Panti, Paolo Fiorenzani, Michele De Luca, Umile Gianfranco Spizzirri, Donatella Restuccia, Francesca Aiello and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anna RamunnoDepartment of Pharmacy, University of Salerno, 84084 Fisciano, SA, Italy.
Rosa Maria VitaleInstitute of Biomolecular Chemistry-National Research Council (ICB-CNR), 80078 Pozzuoli, NA, Italy.ORCID 0000-0001-9243-1307
Pietro AmodeoInstitute of Biomolecular Chemistry-National Research Council (ICB-CNR), 80078 Pozzuoli, NA, Italy.ORCID 0000-0002-6439-7575
Carlo CrescenziDepartment of Pharmacy, University of Salerno, 84084 Fisciano, SA, Italy.ORCID 0000-0001-6950-1506
Alice PantiDepartment of Life Sciences, University of Siena, 53100 Siena, TS, Italy.
Paolo FiorenzaniDepartment of Biotechnology, Chemistry, and Pharmacy, University of Siena, 53100 Siena, TS, Italy.
Michele De LucaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, CS, Italy.ORCID 0000-0001-9036-1595
Umile Gianfranco SpizzirriIonian Department of Law, Economics and Environment, University of Bari Aldo Moro, 74123 Taranto, TA, Italy.ORCID 0000-0002-5447-9497
Donatella RestucciaDepartment of Management, University of Roma La Sapienza, 00161 Rome, RM, Italy.
Francesca AielloDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, CS, Italy.ORCID 0000-0001-6846-5582
Fabio FusiDepartment of Biotechnology, Chemistry, and Pharmacy, University of Siena, 53100 Siena, TS, Italy.ORCID 0000-0002-5737-8309

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The huge amount of citrus peel produced worldwide represents an economic burden for society. However, this agricultural by-product is a rich source of natural molecules, potentially endowed with interesting pharmacological activities. In this regard, we decided to investigate if the polymethoxyflavones contained in citrus peel waste could be exploited as novel vasorelaxant agents. A hydroalcoholic blond orange (

Indexed as

Calcium Channel BlockersCalcium Channels, L-TypeCitrusFlavonesPlant ExtractsAnimalsApigeninFlavonoidsMagnetic Resonance SpectroscopyMolecular Docking SimulationMolecular StructureRatsVasodilator AgentsApigeninCalcium Channel BlockersCalcium Channels, L-TypeFlavonesFlavonoidsL-type calcium channel alpha(1C)nobiletinPlant ExtractssinensetintangeretinVasodilator AgentsCaV1.2 channel blockersdocking studiesmultivariate curve resolutionpolymethoxyflavones

Identifiers

PMID39683852
PMCPMC11642981

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.