Evidence mapPaperPMID 39684250Full record

ReviewInternational journal of molecular sciences2024

Molecular Mechanism of Action of Endocrine-Disrupting Chemicals on the Respiratory System.

Francesco Molinari, Gianluca Antonio Franco, Nicla Tranchida, Rosanna Di Paola, Marika Cordaro

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Unraveling the Core of Endometriosis: The Impact of Endocrine Disruptors.International journal of molecular sciences · 2025
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francesco MolinariDepartment of Veterinary Sciences, University of Messina, Viale SS Annunziata, 98168 Messina, Italy.ORCID 0009-0000-5024-4204
Gianluca Antonio FrancoDepartment of Veterinary Sciences, University of Messina, Viale SS Annunziata, 98168 Messina, Italy.
Nicla TranchidaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno D'Alcontres 31, 98166 Messina, Italy.
Rosanna Di PaolaDepartment of Veterinary Sciences, University of Messina, Viale SS Annunziata, 98168 Messina, Italy.ORCID 0000-0001-6725-8581
Marika CordaroDepartment of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.ORCID 0000-0002-3980-0043

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endocrine-disrupting chemicals (EDCs) are a growing health hazard for humankind and respiratory health in particular. Such chemical compounds are present in the environment and food and may interfere with physiological processes through interference with functions of the endocrine system, making humans more susceptible to various types of diseases. This review aims to discuss the effects of EDCs on the respiratory system. Exposure to EDCs during fetal development and adulthood increases susceptibility to respiratory diseases such as asthma, COPD, and pulmonary fibrosis. EDCs are both multiple and complex in the ways they can act. Indeed, these chemicals may induce oxidative stress, modify cell proliferation and differentiation, interfere with tissue repair, and modulate the inflammatory response. Moreover, EDCs may also break the integrity of the blood-air barrier, allowing noxious substances to penetrate into the lung and thus enhancing the opportunity for infection. In conclusion, the scientific evidence available tends to indicate that EDCs exposure is strongly linked to the initiation of respiratory disease. Further research will be important in discovering the underlying molecular mechanisms and devising preventive and therapeutic measures.

Indexed as

Endocrine DisruptorsRespiratory SystemAnimalsEnvironmental ExposureHumansOxidative StressRespiratory Tract DiseasesEndocrine Disruptorsasthmablood–air barrierCOPDendocrine disruptorsinflammationlung healthoxidative stresspulmonary fibrosis

Identifiers

PMID39684250
PMCPMC11641576

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.