Evidence map›Paper›PMID 39684263›Full record

ArticleInternational journal of molecular sciences2024

Plasmalogens Improve Lymphatic Clearance of Amyloid Beta from Mouse Brain and Cognitive Functions.

Alexander Shirokov, Daria Zlatogosrkaya, Viktoria Adushkina, Elena Vodovozova, Kristina Kardashevskaya, Ruslan Sultanov, Sergey Kasyanov, Inna Blokhina, Andrey Terskov, Maria Tzoy and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Alexander ShirokovInstitute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Prospekt Entuziastov 13, 410049 Saratov, Russia.
Daria ZlatogosrkayaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Viktoria AdushkinaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Elena VodovozovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.ORCID 0000-0003-0164-7423
Kristina KardashevskayaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.ORCID 0000-0003-4348-9902
Ruslan SultanovA.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Palchevskogo Str. 17, 690041 Vladivostok, Russia.
Sergey KasyanovA.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Palchevskogo Str. 17, 690041 Vladivostok, Russia.
Inna BlokhinaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID 0000-0003-1517-0857
Andrey TerskovDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Maria TzoyPhysics Department, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID 0000-0002-4681-6465
Arina EvsyukovaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Alexander DubrovskyShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.
Matvey TuzhilkinDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID 0009-0007-7450-7022
Inna ElezarovaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Alexander DmitrenkoDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Maria ManzhaevaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Valeria KrupnovaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Anastasiia Semiachkina-GlushkovskaiaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.
Egor IlyukovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.
Dmitry MyagkovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.ORCID 0009-0002-7781-6721
Dmitry TuktarovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.
Sergey PopovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.
Tymophey InozemzevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.
Nikita NavolokinDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID 0000-0001-7876-9758
Ivan FedosovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 Moscow, Russia.
Oxana Semyachkina-GlushkovskayaDepartment of Biology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.ORCID 0000-0001-6753-7513

Funding

Russian Science Foundation 23-75-30001
6 · The paper itself

Abstract

Amyloid beta (Aβ) is a neuronal metabolic product that plays an important role in maintaining brain homeostasis. Normally, intensive brain Aβ formation is accompanied by its effective lymphatic removal. However, the excessive accumulation of brain Aβ is observed with age and during the development of Alzheimer's disease (AD) leading to cognitive impairment and memory deficits. There is emerging evidence that plasmalogens (Pls), as one of the key brain lipids, may be beneficial for AD and cognitive aging. Here, we studied the effects of Pls on cognitive functions and the lymphatic clearance of Aβ from the brain of AD mice and mice of different ages. The results showed that Pls effectively reduce brain Aβ levels and facilitate learning in aged but not old mice. In AD mice, Pls improve the lymphatic clearance of Aβ that is accompanied by an increase in general motor activity and an improvement of the emotional status and learning ability. Thus, these findings suggest that Pls could be a promising candidate for the alternative or concomitant therapy of AD and age-related brain diseases to enhance the lymphatic clearance of Aβ from the brain and cognitive functions.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBrainCognitionPlasmalogensAnimalsCognitive DysfunctionDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, TransgenicAmyloid beta-PeptidesPlasmalogensageAlzheimer’s diseaseamyloid betacognitive functionslymphatic clearanceplasmalogens

Identifiers

PMID39684263
PMCPMC11640916

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.