Evidence mapPaperPMID 39684376Full record

ArticleInternational journal of molecular sciences2024

The Role of Medium Polarity in the Efficiency of Albumin Binding with Hydrophobic Ligands: Experimental Studies and a Molecular Dynamics Investigation.

Gabriel Zazeri, Ana Paula Ribeiro Povinelli, Luiza de Carvalho Bertozo, Alan M Jones, Valdecir Farias Ximenes

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gabriel ZazeriDepartamento de Física, Universidade Federal de Roraima (UFRR), Boa Vista 69310-000, RR, Brazil.ORCID 0000-0001-9957-9697
Ana Paula Ribeiro PovinelliInstituto de Biociências Letras e Ciências Exatas, Universidade Estadual Paulista (UNESP), São José do Rio Preto 15054-000, SP, Brazil.ORCID 0000-0001-6282-5380
Luiza de Carvalho BertozoFaculdade de Ciências, Universidade Estadual Paulista (UNESP), Bauru 17033-360, SP, Brazil.
Alan M JonesSchool of Pharmacy, Institute of Clinical Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0002-3897-5626
Valdecir Farias XimenesFaculdade de Ciências, Universidade Estadual Paulista (UNESP), Bauru 17033-360, SP, Brazil.

Funding

Center for Scientific Computing NCC/GridUNESPNational Council for Scientific and Technological Development CNPq, N°: 302121/2022-6 and 422893/2021-8National Institute of Science and Technology - INCT BioNat 465637/2014-0State of Sao Paulo Research Foundation FAPESP, N°: 2024/00959-0
6 · The paper itself

Abstract

This study evaluates how the polarity of the medium affects the binding efficiency of hydrophobic ligands with human serum albumin (HSA). The polarity of the aqueous medium was changed by adding 1,4-dioxane in concentrations of 0%, 10%, and 20%

Indexed as

Hydrophobic and Hydrophilic InteractionsMolecular Dynamics SimulationProtein BindingBinding SitesDioxanesHumansLigandsQuercetinRutinSerum Albumin, Human1,4-dioxaneDioxanesLigandsQuercetinRutinSerum Albumin, Human1,6-diphenyl-1,3,5-hexatrienealbuminentropyhydrophobic effectoctyl gallatequercetinrutin

Identifiers

PMID39684376
PMCPMC11640942

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.