LRRK2 G2019S Mutated iPSC-Derived Endothelial Cells Exhibit Increased α-Synuclein, Mitochondrial Impairment, and Altered Inflammatory Responses.

Tuuli-Maria Sonninen, Sanni Peltonen, Jonna Niskanen, Riikka H Hämäläinen, Jari Koistinaho, Šárka Lehtonen

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

From inserts to chips: microfluidic culture and 3D astrocyte co-culture drive functional and transcriptomic changes in hiPSC-derived endothelial cells.Fluids and barriers of the CNS · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tuuli-Maria SonninenA.I. Virtanen Institute, University of Eastern Finland, 70211 Kuopio, Finland.ORCID 0000-0002-8833-4106

Sanni PeltonenA.I. Virtanen Institute, University of Eastern Finland, 70211 Kuopio, Finland.

Jonna NiskanenA.I. Virtanen Institute, University of Eastern Finland, 70211 Kuopio, Finland.ORCID 0000-0003-2917-7873

Riikka H HämäläinenA.I. Virtanen Institute, University of Eastern Finland, 70211 Kuopio, Finland.ORCID 0000-0002-5102-0672

Jari KoistinahoHelsinki Institute of Life Science, University of Helsinki, 00014 Helsinki, Finland.

Šárka LehtonenA.I. Virtanen Institute, University of Eastern Finland, 70211 Kuopio, Finland.ORCID 0000-0002-5055-9414

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-brain barrier (BBB) serves as an interface between the bloodstream and the central nervous system. It limits the movement of molecules and immune cells, regulates the entry of nutrients, and removes waste products from the brain. The dysfunction of the BBB has been identified in Parkinson's disease (PD) but the role of the BBB and endothelial cells (ECs) has not been well studied.

Indexed as

alpha-SynucleinEndothelial CellsInduced Pluripotent Stem CellsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MitochondriaMutationParkinson DiseaseBlood-Brain BarrierFemaleHumansInflammationMalealpha-SynucleinLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanblood–brain barrierendothelial cellinflammationiPSC cellsMEG3Parkinson’s disease

Identifiers

PMID39684585

DOI10.3390/ijms252312874

PMCPMC11641647

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.