Identification of Functional Variants Between Tong Sheep and Hu Sheep by Whole-Genome Sequencing Pools of Individuals.

Xiaoqin Tang, Shuhui Wang, Xiaohua Yi, Qi Li, Xiuzhu Sun

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Regulatory element map of sheep reproductive tissues: functional annotation of tissue-specific strong active enhancers.Frontiers in veterinary science · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaoqin TangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.

Shuhui WangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.

Xiaohua YiCollege of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.ORCID 0000-0002-6222-5112

Qi LiCollege of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.

Xiuzhu SunCollege of Grassland Agriculture, Northwest A&F University, Yangling, Xianyang 712100, China.

Funding

China Agriculture Research System CARS-34Integrated Demonstration Project of Shaanxi Provincial Key Research and Development Program 2018ZDXM-NY-040

6 · The paper itself

Abstract

Tong sheep, known for their superior meat quality and disease resilience, face breeding challenges due to low prolificacy, unlike Hu sheep, which exhibit higher fertility and growth rates. This study identified over 700,000 genetic variants between these breeds through pooled whole-genome sequencing. Functional analysis reveals key differences in pathways related to fat metabolism, insulin signaling, and cell cycle regulation. Notable findings include unique microRNA variants (miR-1185-3p in Tong sheep and miR-487-5p in Hu sheep), with the miR-487-5p mutation potentially regulating KITLG, a fertility-related gene. These results suggest that non-coding RNA mutations contribute to phenotypic differences and provide a genomic foundation for molecular-assisted selection to improve Tong sheep breeding programs.

Indexed as

MicroRNAsWhole Genome SequencingAnimalsBreedingGenetic VariationMutationPhenotypePolymorphism, Single NucleotideSheepMicroRNAsHu sheepMASmiRNAPool-seqTong sheep

Identifiers

PMID39684630

DOI10.3390/ijms252312919

PMCPMC11641353

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.