Evidence map›Paper›PMID 39684780›Full record

ArticleInternational journal of molecular sciences2024

Single-Cell RNA Sequencing of PBMCs Identified Junction Plakoglobin (JUP) as Stratification Biomarker for Endometriosis.

Thomas Andrieu, Angelo Duo, Lea Duempelmann, Magdalena Patzak, Flurina Annacarina Maria Saner, Jitka Skrabalova, Cinzia Donato, Peter Nestorov, Michael D Mueller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Junction Plakoglobin - A Dual-Role Player in Cancer Biology.International journal of surgery (London, England) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas AndrieuEndometriosis & Gynaecological Oncology Laboratory (EndoGO), Department for Biomedical Research (DBMR), University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.ORCID 0000-0002-1187-2272
Angelo DuoScailyte AG, True Precision Medicine Through Single-Cell Science, Lichtstrasse 35, 4056 Basel, Switzerland.
Lea DuempelmannEndometriosis & Gynaecological Oncology Laboratory (EndoGO), Department for Biomedical Research (DBMR), University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
Magdalena PatzakEndometriosis & Gynaecological Oncology Laboratory (EndoGO), Department for Biomedical Research (DBMR), University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
Flurina Annacarina Maria SanerEndometriosis & Gynaecological Oncology Laboratory (EndoGO), Department for Biomedical Research (DBMR), University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.ORCID 0000-0003-2469-9824
Jitka SkrabalovaEndometriosis & Gynaecological Oncology Laboratory (EndoGO), Department for Biomedical Research (DBMR), University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
Cinzia DonatoScailyte AG, True Precision Medicine Through Single-Cell Science, Lichtstrasse 35, 4056 Basel, Switzerland.
Peter NestorovScailyte AG, True Precision Medicine Through Single-Cell Science, Lichtstrasse 35, 4056 Basel, Switzerland.
Michael D MuellerEndometriosis & Gynaecological Oncology Laboratory (EndoGO), Department for Biomedical Research (DBMR), University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.ORCID 0000-0003-1947-1315

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to identify unique characteristics in the peripheral blood mononuclear cells (PBMCs) of endometriosis patients and develop a non-invasive early diagnostic tool. Using single-cell RNA sequencing (scRNA-seq), we constructed the first single-cell atlas of PBMCs from endometriosis patients based on 107,964 cells and 25,847 genes. Within CD16

Indexed as

BiomarkersEndometriosisLeukocytes, MononuclearSingle-Cell AnalysisAdultAscitic FluidCA-125 AntigenFemalegamma CateninHumansMiddle AgedMonocytesOvarian NeoplasmsReceptors, IgGSequence Analysis, RNABiomarkersCA-125 Antigengamma CateninJUP protein, humanReceptors, IgGadenomyosisdiagnostic biomarkersendometriosisJunctional plakoglobin (JUP)peripheral blood mononuclear cells (PBMCs)single-cell RNA-sequencing (scRNA-seq)

Identifiers

PMID39684780
PMCPMC11641628

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.