Evidence map›Paper›PMID 39684781›Full record

ArticleInternational journal of molecular sciences2024

AhR-Induced Anti-Inflammatory Effects on a Caco-2/THP-1 Co-Culture Model of Intestinal Inflammation Are Mediated by PPARγ.

Gustavo Henrique Oliveira da Rocha, Claudia Müller, Susanne Przybylski-Wartner, Heidrun Schaller, Sina Riemschneider, Jörg Lehmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Preliminary Studies on In Vitro Antibacterial Activity AgainstPharmaceuticals (Basel, Switzerland) · 2026
    Article
  7. Review
  8. Intestinal CD4Molecular medicine reports · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gustavo Henrique Oliveira da RochaDepartment of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, 04103 Leipzig, Germany.
Claudia MüllerDepartment of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, 04103 Leipzig, Germany.ORCID 0000-0003-2670-5626
Susanne Przybylski-WartnerDepartment of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, 04103 Leipzig, Germany.
Heidrun SchallerDepartment of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, 04103 Leipzig, Germany.
Sina RiemschneiderDepartment of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, 04103 Leipzig, Germany.ORCID 0009-0004-6194-1282
Jörg LehmannDepartment of Preclinical Development and Validation, Fraunhofer Institute for Cell Therapy and Immunology, 04103 Leipzig, Germany.ORCID 0000-0001-8560-648X

Funding

Alexander von Humboldt Foundation / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.699297/2022-01Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. / Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD_CED-AhR
6 · The paper itself

Abstract

The aryl hydrocarbon receptor (AhR) and the peroxisome proliferator-activated receptor γ (PPARγ) are ligand-activated transcription factors that have in recent years been investigated for their anti-inflammatory properties for treatment of inflammatory bowel diseases (IBDs). These are globally prevalent chronic maladies of the gut that lack cost-efficient therapeutical options capable of inducing long-term remission. In the present study, we used an in vitro Transwell

Indexed as

Anti-Inflammatory AgentsCoculture TechniquesLipopolysaccharidesPPAR gammaReceptors, Aryl HydrocarbonBasic Helix-Loop-Helix ProteinsCaco-2 CellsCarbazolesHumansInflammationInflammatory Bowel DiseasesInterleukin-6MacrophagesTHP-1 Cells6-formylindolo(3,2-b)carbazoleAHR protein, humanAnti-Inflammatory AgentsBasic Helix-Loop-Helix ProteinsCarbazolesInterleukin-6LipopolysaccharidesPPAR gammaPPARG protein, humanReceptors, Aryl Hydrocarbonaryl hydrocarbon receptorinflammatory bowel diseaseperoxisome proliferator-activated receptor gamma

Identifiers

PMID39684781
PMCPMC11642145

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.