Evidence map›Paper›PMID 39684827›Full record

ArticleInternational journal of molecular sciences2024

GLI3 Is Required for M2 Macrophage Polarization and M2-Mediated Waldenström Macroglobulinemia Growth and Survival.

Ava J Boutilier, Mohammad Raad, Kailey E Paar, Stephan J Matissek, Cameron E Banks, Allison L Carl, Jenna M Murray, Anna D Metzler, Katja U Koeppen, Mamta Gupta and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ava J BoutilierDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.ORCID 0000-0001-6307-9463
Mohammad RaadDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.ORCID 0000-0001-6530-3326
Kailey E PaarDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.
Stephan J MatissekDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.
Cameron E BanksDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.
Allison L CarlDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.ORCID 0009-0007-5983-9053
Jenna M MurrayDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.
Anna D MetzlerDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.ORCID 0000-0003-1633-2213
Katja U KoeppenDepartment of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Mamta GuptaDepartment of Biochemistry and Molecular Medicine, George Washington University's Cancer Center (GWCC), Washington, DC 20037, USA.
Sherine F ElsawaDepartment of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH 03824, USA.ORCID 0000-0002-3917-3078

Funding

TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI Sean Stoddart Coleman Edington · 2017 to 2026
$22.8M
NIGMS NIH HHS P20 GM113131NIH HHS P20 GM113131
6 · The paper itself

Abstract

Waldenstrom macroglobulinemia (WM) is a non-Hodgkin B-cell lymphoma, characterized by bone marrow infiltration with plasma cells and lymphocytes. The tumor microenvironment (TME) plays an important role in mediating WM cell biology, but the effects of macrophages on WM biology remains unclear. Here, we investigated the effects of macrophages on WM growth and survival and identified a novel role for transcription factor GLI3 in macrophage polarization. We found that co-culture of M0 and M2 macrophages promoted WM cell growth and survival, and co-culture WM cells with M0 macrophages induced M2-like phenotypes. Interestingly, GLI3 expression was induced in M2 macrophages (not M1), leading us to perform analysis of macrophages from mice lacking Gli3 in myeloid cells (

Indexed as

Cell ProliferationMacrophagesWaldenstrom MacroglobulinemiaZinc Finger Protein Gli3AnimalsCell Line, TumorCell SurvivalCoculture TechniquesHumansMacrophage ActivationMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsTumor MicroenvironmentGLI3 protein, humanNerve Tissue ProteinsZinc Finger Protein Gli3GLI proteinmacrophage polarizationnon-Hodgkin lymphomatumor microenvironmentWaldenstrom macroglobulinemia

Identifiers

PMID39684827
PMCPMC11641819

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.