Evidence map›Paper›PMID 39685877›Full record

ArticleJournal of clinical medicine2024

Management of Hypercholesterolemia in Patients with Coronary Artery Disease: A Glimpse into the Future.

Alessandro Sciahbasi, Paola Russo, Michela Zuccanti, Laura Chiorazzo, Francesco Maria Castelli, Antonino Granatelli

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alessandro SciahbasiInterventional Cardiology, Sandro Pertini Hospital, 00157 Rome, Italy.ORCID 0000-0002-7964-4479
Paola RussoCardiology, Sant'Andrea Hospital, 00189 Rome, Italy.
Michela ZuccantiCardiology, Sant'Andrea Hospital, 00189 Rome, Italy.
Laura ChiorazzoCardiology Unit, University of L'Aquila, 67100 L'Aquila, Italy.
Francesco Maria CastelliCardiology Unit, University of Pisa, 56126 Pisa, Italy.ORCID 0009-0001-7362-184X
Antonino GranatelliInterventional Cardiology, Sandro Pertini Hospital, 00157 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardio-cerebral vascular diseases due to atherosclerosis are still the leading cause of death worldwide. Low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B have been identified as the primary factors responsible for the atherosclerotic process, with a causal effect. Many drugs aimed at reducing LDL-C levels are already on the market, acting in different ways in terms of mechanism of action, efficacy, and safety. Moreover, new lipid-lowering agents and new technologies in the fields of gene editing and immunotherapy are currently under investigation. A more recent biomarker associated with an increased risk of plaque generation, progression, and subsequent ASCVD is the lipoprotein (a) and, in the next few years, it will be the new target of pharmacological therapy. The aim of this review is to present the landscape of therapies already approved to reduce LDL-C levels, evaluating their efficacy, tolerability, and indications. Moreover, we take a glimpse into the future to evaluate experimental novel therapies to lower LDL-C levels that will be approved in the next few years or are under clinical evaluation.

Indexed as

alirocumabbempedoic acidevolocumabezetimibehypercholesterolemiainclisiranLipoprotein (a)PCSK9istatin

Identifiers

PMID39685877
PMCPMC11642370

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.