Evidence map›Paper›PMID 39687336›Full record

ArticleRSC advances2024

Pyrazine derivative synthesis in a continuous-flow system: a green synthesis of pyrazinamide from pyrazine esters and amines catalyzed by Lipozyme® TL IM from

Ao-Ying Zhang, Zong-Hao Huang, Li-Hua Du, Hang Lin, Han-Jia Xie, Bing-Lin Yan, Miao Miao Xue, Lin Wang, Wen-Xuan Shao, Guo-Neng Fu and 1 more

Abstract read
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ao-Ying ZhangCollege of Pharmaceutical Science, ZheJiang University of Technology Zhejiang Hangzhou 310014 China orgdlh@zjut.edu.cn +86-571-88320903 +86-189-690-693-99.
Zong-Hao HuangCollege of Pharmaceutical Science, ZheJiang University of Technology Zhejiang Hangzhou 310014 China orgdlh@zjut.edu.cn +86-571-88320903 +86-189-690-693-99.
Li-Hua DuCollege of Pharmaceutical Science, ZheJiang University of Technology Zhejiang Hangzhou 310014 China orgdlh@zjut.edu.cn +86-571-88320903 +86-189-690-693-99.ORCID https://orcid.org/0000-0001-6767-2248
Hang LinCollege of Pharmaceutical Science, ZheJiang University of Technology Zhejiang Hangzhou 310014 China orgdlh@zjut.edu.cn +86-571-88320903 +86-189-690-693-99.
Han-Jia XieCollege of Pharmaceutical Science, ZheJiang University of Technology Zhejiang Hangzhou 310014 China orgdlh@zjut.edu.cn +86-571-88320903 +86-189-690-693-99.
Bing-Lin YanCollege of Pharmaceutical Science, ZheJiang University of Technology Zhejiang Hangzhou 310014 China orgdlh@zjut.edu.cn +86-571-88320903 +86-189-690-693-99.
Miao Miao XueCollege of Pharmaceutical Science, ZheJiang University of Technology Zhejiang Hangzhou 310014 China orgdlh@zjut.edu.cn +86-571-88320903 +86-189-690-693-99.
Lin WangCollege of Pharmaceutical Science, ZheJiang University of Technology Zhejiang Hangzhou 310014 China orgdlh@zjut.edu.cn +86-571-88320903 +86-189-690-693-99.
Wen-Xuan ShaoCollege of Pharmaceutical Science, ZheJiang University of Technology Zhejiang Hangzhou 310014 China orgdlh@zjut.edu.cn +86-571-88320903 +86-189-690-693-99.
Guo-Neng FuCollege of Pharmaceutical Science, ZheJiang University of Technology Zhejiang Hangzhou 310014 China orgdlh@zjut.edu.cn +86-571-88320903 +86-189-690-693-99.
Xi-Ping LuoZhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, Zhejiang A&F University Zhejiang Hangzhou 311300 China.ORCID https://orcid.org/0009-0005-8310-7034

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyrazinamide derivatives have been extensively studied for their biological activities, such as anti-tuberculosis activity and antiviral activities. In this work, a continuous-flow system was developed for the synthesis of pyrazinamide derivatives from pyrazine esters and amines (aliphatic amine, benzylamines and morpholine) catalyzed by Lipozyme® TL IM from

Identifiers

PMID39687336
PMCPMC11648184

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.